Evidence map›Paper›PMID 30238180›Full record

ArticleJournal of autism and developmental disorders2019

Sensitivity and Specificity of the ADOS-2 Algorithm in a Large German Sample.

Juliane E Medda, Hannah Cholemkery, Christine M Freitag

Abstract readEvaluation Study
In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  17. Exclusion of females in autism research: Empirical evidence for a "leaky" recruitment-to-research pipeline.Autism research : official journal of the International Society for Autism Research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juliane E MeddaDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Centre of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. juliane.medda@kgu.de.
Hannah CholemkeryDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Centre of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Centre of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Funding

Bundesministerium für Bildung und Forschung EUHFAUTISM-01EW1105Deutsche Forschungsgemeinschaft FR2069/2-1Universität des Saarlandes T6 03 10 00-45
6 · The paper itself

Abstract

The aim of the present study was to establish diagnostic validity of the new algorithm of the Autism Diagnostic Observation Scale, the ADOS-2, to differentiate between ASD and other clinically relevant psychiatric and developmental disorders in a large German sample. Validity of ADOS and ADOS-2 diagnostic algorithms was established in 826 individuals (n = 455 autism, n = 216 autism spectrum, n = 155 non-ASD patients) by receiver operating curves. Confidence intervals overlapped largely for ADOS and ADOS-2 algorithms, confirming diagnostic validity of both algorithms. Adding information of the Social Communication Questionnaire and the Social Responsiveness Scale resulted in slightly improved classification rates for autism in Module 4. We thus replicated previous findings of the diagnostic validity of the ADOS-2 algorithms.

Indexed as

AlgorithmsAutistic DisorderChildChild, PreschoolFemaleGermanyHumansMalePsychometricsSensitivity and SpecificitySurveys and QuestionnairesAutism spectrum disorderChild psychiatric disorderDiagnostic validityPsychometric assessment

Identifiers

PMID30238180
PMCPMC6373322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.