ReviewAnnals of intensive care2018
Renal failure in critically ill patients, beware of applying (central venous) pressure on the kidney.
Review in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07722325 (Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Elevated central venous pressure is associated with increased mortality and acute kidney injury in critically ill patients: a meta-analysis.Critical care (London, England) · 2020Pooled it
- Development and External Validation of an Interpretable Machine Learning Framework for Predicting Pneumothorax-Associated Acute Kidney Injury: A Multicenter Retrospective Study.Journal of clinical medicine · 2026Article
- Central Venous Pressure Referencing in the Lateral Position: Comparison With Direct Right Atrial Pressure in Mechanically Ventilated ICU Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- Efficiency and hemodynamics of dual drainage venovenous ECMO: A computational parametric study.PloS one · 2026Article
- Exploring the Role of Central Venous Pressure in Cardiac Surgery-Associated Acute Kidney Injury: A Comprehensive Scoping Review.Archives of Iranian medicine · 2025Article
- The Prevalence of Systemic Venous Congestion Post Kidney Transplant Detected by Point of Care Ultrasound (POCUS).POCUS journal · 2025Article
- Central Venous Pressure as a Predictor of Acute Kidney Injury in Cardiac Surgery: A Systematic Review of Observational Studies.Diagnostics (Basel, Switzerland) · 2025Review
- Association between intraoperative fluid management and postoperative outcomes in living kidney donors: a retrospective cohort study.Scientific reports · 2025Article
- Efficacy and validation of a clinical model to predict acute kidney injury in severe pneumonia requiring mechanical ventilation in elderly patients: a multicenter retrospective observational analysis.Frontiers in medicine · 2025Article
- Construction of a right ventricular function assessment model in patients undergoing invasive mechanical ventilation based on VExUS grading and the classification and regression tree algorithm.Frontiers in cardiovascular medicine · 2025Article
- The right heart perspective in chronic cardiorenal syndrome: the key role of right heart function and tricuspid regurgitation innovation.Frontiers in cardiovascular medicine · 2025Review
- Correlation between right atrial pressure measured via right heart catheterization and venous excess ultrasound, inferior vena cava diameter, and ultrasound-measured jugular venous pressure: a prospective observational study.The ultrasound journal · 2024Article
- Decoding VExUS: a practical guide for excelling in point-of-care ultrasound assessment of venous congestion.The ultrasound journal · 2024Review
- Changes in portal pulsatility index induced by a fluid challenge in patients with haemodynamic instability and systemic venous congestion: a prospective cohort study.Annals of intensive care · 2024Article
- Can central venous pressure help identify acute right ventricular dysfunction in mechanically ventilated critically ill patients?Annals of intensive care · 2024Article
- The Importance of Venous Reflux Status Evaluation in the Intensive Care Unit.Aging and disease · 2024Review
- Tricuspid Regurgitation and Kidney Transplant Recipient Outcomes.Kidney medicine · 2024Article
- Influence of fluid accumulation on major adverse kidney events in critically ill patients - an observational cohort study.Annals of intensive care · 2024Article
- The Association of the Pulmonary Artery Pulsatility Index and Right Ventricular Function after Cardiac Surgery.Critical care research and practice · 2024Article
- Incidence and Determinants of Acute Kidney Injury after Prone Positioning in Severe COVID-19 Acute Respiratory Distress Syndrome.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central venous pressure (CVP) is traditionally used as a surrogate of intravascular volume. CVP measurements therefore are often applied at the bedside to guide fluid administration in postoperative and critically ill patients. Pursuing high CVP levels has recently been challenged. A high CVP might impede venous return to the heart and disturb microcirculatory blood flow which may cause tissue congestion and organ failure. By imposing an increased "afterload" on the kidney, an elevated CVP will particularly harm kidney hemodynamics and promote acute kidney injury (AKI) even in the absence of volume overload. Maintaining the lowest possible CVP should become routine to prevent and treat AKI, especially when associated with septic shock, cardiac surgery, mechanical ventilation, and intra-abdominal hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.