Evidence map›Paper›PMID 30238168›Full record

ReviewPharmaceutical research2018

Nanotechnology in Tuberculosis: State of the Art and the Challenges Ahead.

Estefania Grotz, Nancy Tateosian, Nicolas Amiano, Maximiliano Cagel, Ezequiel Bernabeu, Diego A Chiappetta, Marcela A Moretton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Nanomedicines for Infectious Diseases.Pharmaceutical research · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Estefania GrotzFacultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Universidad de Buenos Aires, Buenos Aires, Argentina.
Nancy TateosianConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Nicolas AmianoConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Maximiliano CagelFacultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ezequiel BernabeuFacultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Universidad de Buenos Aires, Buenos Aires, Argentina.
Diego A ChiappettaFacultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Universidad de Buenos Aires, Buenos Aires, Argentina.
Marcela A MorettonFacultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Universidad de Buenos Aires, Buenos Aires, Argentina. marcelamoretton@gmail.com.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) remains as the second most-deadly infection right behind the HIV/AIDS. Actually, in 2016, TB incidence was estimated in 10.4 million cases. Although an efficient and low-cost TB pharmacotherapy has been available for the last 50 years, the development of multi- and extra-drug-resistant Mycobacterium tuberculosis (Mtb) strains has put on the spot the necessity of improved TB regimens. In this framework, this review article presents the main relevant research outcomes of nanotechnology in TB. The novel delivery systems for antituberculosis drugs have been discussed. Moreover, the active-targeted nanomedicines to the Mtb reservoirs enlighten the possibility to eradicate low-replicant mycobacteria and diminish latent TB. Finally, we present an overview of the TB socio-economic impact and the cost-related features of TB regimens associated with the use of nanoformulations.

Indexed as

AnimalsAntitubercular AgentsDrug Delivery SystemsDrug DiscoveryDrug Resistance, BacterialHumansLiposomesMicellesMycobacterium tuberculosisNanomedicineNanoparticlesNanotechnologyTuberculosisAntitubercular AgentsLiposomesMicellesactive targetingnanotechnologyrespirable nanocarrierstuberculosis

Identifiers

PMID30238168
OpenAlexW2889626807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.