ArticleHeliyon2018
Antibiotic multidrug resistance in the cystic fibrosis airway microbiome is associated with decreased diversity.
Article in Heliyon, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Article
- Chronic Airway Infection and Resistance Pattern in Children and Adults with Cystic Fibrosis in Oman: A Single-center Cross-sectional Study.Oman medical journal · 2025Article
- Comparison of culture and PCR-DGGE methods to evaluate the airways of cystic fibrosis patients and determination of their antibiotic resistance profile.Iranian journal of microbiology · 2023Article
- AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis.Journal of clinical microbiology · 2023Article
- Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis.Scientific reports · 2023Observational
- Article
- A pilot study investigating the effects of a manuka honey sinus rinse compared to a standard sinus rinse on sino-nasal outcome test scores in cystic fibrosis patients.Pilot and feasibility studies · 2022Article
- Measuring the impact of an empiric antibiotic algorithm for pulmonary exacerbation in children and young adults with cystic fibrosis.Pediatric pulmonology · 2022Article
- Genomic diversity and antimicrobial resistance ofMicrobial genomics · 2022Article
- Bacteriophage: A new therapeutic player to combat neutrophilic inflammation in chronic airway diseases.Frontiers in medicine · 2022Review
- Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease.Frontiers in pharmacology · 2022Article
- Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Article
- Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability.Microbiology spectrum · 2021Article
- Genomic Diversity and Antimicrobial Resistance ofmSystems · 2021Article
- Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2021Review
- Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids.Pediatric research · 2021Article
- Longitudinal analysis of sinus microbiota post endoscopic surgery in patients with cystic fibrosis and chronic rhinosinusitis: a pilot study.Respiratory research · 2021Article
- Lung Microbiome in Cystic Fibrosis.Life (Basel, Switzerland) · 2021Review
- Liquid Chromatography Mass Spectrometry Detection of Antibiotic Agents in Sputum from Persons with Cystic Fibrosis.Antimicrobial agents and chemotherapy · 2021Article
- The Anti-Pseudomonal Peptide D-BMAP18 Is Active in Cystic Fibrosis Sputum and Displays Anti-Inflammatory In Vitro Activity.Microorganisms · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundCystic fibrosis (CF) is associated with significant morbidity and early mortality due to recurrent acute and chronic lung infections. The chronic use of multiple antibiotics increases the possibility of multidrug resistance (MDR). Antibiotic susceptibility determined by culture-based techniques may not fully represent the resistance profile. The study objective was to detect additional antibiotic resistance using molecular methods and relate the presence of MDR to airway microbiome diversity and pulmonary function.
methodsBacterial DNA was extracted from sputum samples and amplified for the V4 region of the 16S rRNA gene. An qPCR array was used to detect antibiotic resistance genes. Clinical culture results and pulmonary function were also noted for each encounter.
resultsSix study participants contributed samples from 19 encounters. Those samples with MDR (n = 7) had significantly lower diversity measured by inverse Simpson's index than those without (n = 12) (2.193 ± 0.427 vs 6.023 ± 1.564, p = 0.035). Differential abundance showed that samples with MDR had more
conclusionsThe presence of MDR within the CF airway microbiome was associated with decreased microbial diversity, the presence of
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