ReviewEye and vision (London, England)2018
Bowman layer transplantation in the treatment of keratoconus.
Review in Eye and vision (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Acellular Bowman Layer and Descemet Membrane Allografts for Non-Ectatic Anterior Corneal Diseases: A Narrative Review of Emerging Evidence.Ophthalmology and therapy · 2026Review
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Manual Bowman-stroma onlay transplant for the treatment of symptoms post-radial keratotomy: proof of concept and preliminary results.International journal of ophthalmology · 2026Article
- New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration.Stem cell research & therapy · 2023Review
- Screening and identification of genes related to ferroptosis in keratoconus.Scientific reports · 2023Article
- Graft rejection in component keratoplasty.Indian journal of ophthalmology · 2023Review
- An Overview of Corneal Transplantation in the Past Decade.Clinics and practice · 2023Review
- Intrastromal Corneal Ring Segment Implantation in a Patient with the Bowman Layer Inlay Transplantation for Keratoconus.Case reports in ophthalmological medicine · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
- Current approaches in the management of patients with keratoconus.Medicine and pharmacy reports · 2022Review
- Biomechanical Evaluation of Decellularized and Crosslinked Corneal Implants Manufactured From Porcine Corneas as a Treatment Option for Advanced Keratoconus.Frontiers in bioengineering and biotechnology · 2022Article
- Commentary: Femtosecond laser-assisted stromal implants for keratoconus - Customized treatment for the future!Indian journal of ophthalmology · 2021Article
- Comments on: Are we treating the effect and neglecting the cause of keratoconus?Indian journal of ophthalmology · 2021Article
- Corneal Donation: Current Guidelines and Future Direction.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Corneal Biomechanical Assessment with Ultra-High-Speed Scheimpflug Imaging During Non-Contact Tonometry: A Prospective Review.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Establishing a Porcine Eye Model for Manual Sub-Bowman Layer Photorefractive Keratomileusis.Journal of ophthalmology · 2020Article
- Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus.Cornea · 2019Article
- Advantages of femtosecond laser in various corneal transplantation procedures: A narrative literature review.Taiwan journal of ophthalmologyReview
- Bowman's membrane lenticule tuck-in: A new approach for the management of neurotrophic ulcers.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several treatment options corresponding to the grade of keratoconus have been established. These are ultra-violet corneal crosslinking and intracorneal ring segments for mild to moderate keratoconus, and penetrating keratoplasty or deep anterior lamellar keratoplasty for the more advanced cases of keratoconus. Bowman layer transplantation was developed as a procedure for patients with advanced, progressive keratoconus. The technique consists of transplanting an isolated donor Bowman layer into a mid-stromal pocket of a keratoconic cornea resulting in corneal flattening and stabilization against further ectasia. Thus, it aims at corneal stabilization in eyes with advanced keratoconus, and enabling continued contact lens wear for normal visual functionality. By being a sutureless procedure and using an acellular graft, it potentially avoids commonly known suture and graft-related complications of penetrating or deep anterior lamellar keratoplasty. The treatment seems to be a promising option in the management of advanced keratoconus in order to postpone or prevent a more invasive corneal surgery, while minimizing the risk of complications and allowing less stringent surveillance and less intensive medical therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.