Evidence map›Paper›PMID 30237802›Full record

ReviewFrontiers in immunology2018

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based.

Massimo Fioranelli, Anna G Bottaccioli, Francesco Bottaccioli, Maria Bianchi, Miriam Rovesti, Maria G Roccia

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06919055 (Biofeedback With Heart Sound Following Trauma), which is not on this map. Cited by 162 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 4 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06919055 narecruitingnot on this mapstarted 2025, after this paper: background citation

Biofeedback With Heart Sound Following Trauma

TypeinterventionalSponsorFatma ÖzcanRan2025 to 2025Enrolled42ConditionsYoung Earthquake SurvivorsArmsPCG auditory stimulation, MHR stimulation, Control-no treatment
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 4 syntheses or guidelines pooled it, 333 citations in OpenAlex.

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  13. Inflammaging and Cardiovascular Risk in Old Women.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Massimo FioranelliDepartment of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, Italy.
Anna G BottaccioliSocietà Italiana di Psiconeuroendocrinoimmunologia, Rome, Italy.
Francesco BottaccioliSocietà Italiana di Psiconeuroendocrinoimmunologia, Rome, Italy.
Maria BianchiDepartment of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, Italy.
Miriam RovestiDepartment of Dermatology, University of Parma, Parma, Italy.
Maria G RocciaDepartment of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, Italy.
Marconi University · ITIstituto Psicoanalitico per le Ricerche Sociali · ITSapienza University of Rome · ITUniversity of L'Aquila · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent findings have deeply changed the current view of coronary heart disease, going beyond the simplistic model of atherosclerosis as a passive process involving cholesterol build-up in the subintimal space of the arteries until their final occlusion and/or thrombosis and instead focusing on the key roles of inflammation and the immune system in plaque formation and destabilization. Chronic inflammation is a typical hallmark of cardiac disease, worsening outcomes irrespective of serum cholesterol levels. Low-grade chronic inflammation correlates with higher incidence of several non-cardiac diseases, including depression, and chronic depression is now listed among the most important cardiovascular risk factors for poor prognosis among patients with myocardial infarction. In this review, we include recent evidence describing the immune and endocrine properties of the heart and their critical roles in acute ischaemic damage and in post-infarct myocardial remodeling. The importance of the central and autonomic regulation of cardiac functions, namely, the neuro-cardiac axis, is extensively explained, highlighting the roles of acute and chronic stress, circadian rhythms, emotions and the social environment in triggering acute cardiac events and worsening heart function and metabolism in chronic cardiovascular diseases. We have also included specific sections related to stress-induced myocardial ischaemia measurements and stress cardiomyopathy. The complex network of reciprocal interconnections between the heart and the main biological systems we have presented in this paper provides a new vision of cardiovascular science based on psychoneuroendocrineimmunology.

Indexed as

InflammationNeuroendocrinologyPsychoneuroimmunologyStress, PsychologicalAnimalsCircadian RhythmCoronary Artery DiseaseHeartHumansLipid MetabolismMyocardial IschemiaMyocardiumRisk FactorsSocial Environmentatherosclerosiscoronary diseasecytokinesimmune systeminflammationpsychoneuroendocrineimmunologystress

Identifiers

PMID30237802
PMCPMC6135895
OpenAlexW2890909864

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.