ArticleBioinformation2018
Binding property of HIV p24 and Reverse transcriptase by chalcones from Pongamia pinnata seeds.
Article in Bioinformation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis.Heliyon · 2023Review
- Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growthActa pharmaceutica Sinica. B · 2022Article
- Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific.Marine drugs · 2022Review
- Flavonoids as Potential Antiviral Agents for Porcine Viruses.Pharmaceutics · 2022Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV remains a challenging life threatening viral agent for humans despite available anti HIV drugs. The known effective drug named HAART clears the circulating viruses but not the intracellular viruses. Therefore, it is of interest to identify molecules with improved anti-HIV activity from natural plant sources. Hence, we studied the anti-HIV potency of an Indian medicinal plant named Pongamia pinnata. Aqueous extracts were made from leaf, seed and roots of Pongmia pinnata and screened for anti HIV-1 activity using HIV-1 p24 and reverse transcriptase (RT) inhibition assays. Further, the active chalcone derivatives namely, P24 protein and RT enzymes showed promising binding score against Glabarachalcone and Karanijin. Among these extracts, P. pinnta aqueous seed extracts have shown HIV-1 p24 inhibition at 66.9 ± 4.4 percentage. However, RT inhibition assay showed only 36.8%. Hence, the HIV-1 p24 inhibition infers either the prevention of virus entry or inhibits other enzymes and or interferes with virion assembly.
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