ArticleScientific reports2018
Kinetics of the invasion and egress processes of Babesia divergens, observed by time-lapse video microscopy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Acquired motility ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases.Nature microbiology · 2026Article
- Application of Multiplatform Mass Spectrometry to the Study ofInternational journal of molecular sciences · 2025Article
- Elucidating the functional role of the novel BdP50 protein and extracellular vesicles in the human erythrocyte infection by Babesia divergens.PLoS neglected tropical diseases · 2025Article
- Imaging 3D cell cultures with optical microscopy.Nature methods · 2025Review
- How to Detect Antibodies AgainstOpen forum infectious diseases · 2024Article
- Article
- Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions.Blood advances · 2023Article
- Babesia, Theileria, Plasmodium and Hemoglobin.Microorganisms · 2022Article
- Extraordinary high level of propagation ofParasitology · 2022Article
- The Piroplasmida Babesia, Cytauxzoon, and Theileria in farm and companion animals: species compilation, molecular phylogeny, and evolutionary insights.Parasitology research · 2022Review
- Major Surface Antigens in ZoonoticPathogens (Basel, Switzerland) · 2022Review
- The Cross-Species Immunity During AcuteFrontiers in cellular and infection microbiology · 2022Article
- Article
- Exogenous nitric oxide stimulates early egress of Eimeria tenella sporozoites from primary chicken kidney cells in vitro.Parasite (Paris, France) · 2021Article
- Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites:Frontiers in cellular and infection microbiology · 2021Review
- Integration of Genomic and Transcriptomic Data to Elucidate Molecular Processes in Babesia divergens.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Four-Dimensional Characterization of themSphere · 2020Article
- Geometry-Aware Cell Detection with Deep Learning.mSystems · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Based on confocal fluorescence and bright field video microscopy, we present detailed observations on the processes of invasion and egress of erythrocytes by the apicomplexan parasite Babesia divergens. Time-lapse images reveal numerous unexpected findings associated with the dynamics of B. divergens and its ability to manipulate the erythrocyte during both processes in its asexual cycle under in vitro conditions. Despite the speed at which these processes occur and the small size of the parasite, we capture infective merozoites moving vigorously and causing striking deformations in the erythrocyte's plasma membrane during an active invasion. We also observed intraerythrocytic dynamic stages as paired pyriforms, double paired pyriforms, tetrads, unattached pyriform sister cells and multiple parasite stages resulting in the release of large numbers of merozoites over a short period. Of considerable interest is that time-lapse images reveal a novel mechanism of egress used by B. divergens to exit the human erythrocyte. The release occurs when B. divergens parasites establish contacts with the plasma membrane of the erythrocyte from within, before exiting the cell. Visualization and analysis of the images enabled us to obtain useful information and broaden our knowledge of complex and crucial events involved with parasitisation of human erythrocytes by B. divergens.
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