ArticleScientific reports2018
The synergic effects of frailty on disability associated with urbanization, multimorbidity, and mental health: implications for public health and medical care.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The prevalence of disability in older adults with multimorbidity: a meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Tailoring multidomain intervention programs to reduce cognitive and physical decline in older adults: Examining rural-urban differences in a nationwide cluster-randomized controlled trial.The journal of prevention of Alzheimer's disease · 2025Trial
- Article
- Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis.Hereditas · 2025Article
- Synergistic effects of cognitive frailty and comorbidities on disability: a community-based longitudinal study.BMC geriatrics · 2024Article
- Is the combination of depression symptoms and multimorbidity associated with the increase of the prevalence of functional disabilities in Brazilian older adults? A cross-sectional study.Frontiers in aging · 2023Article
- Examining Racial Disparities in Historical Change of Mental and Physical Health Across Midlife and Old Age in the United States.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Arthritis, physical function, and disability among older Mexican Americans over 23 years of follow-up.Ethnicity & health · 2022Article
- The Effect of Urbanization on Health Care Expenditure: Evidence From China.Frontiers in public health · 2022Article
- Subtypes of Premorbid Metabolic Syndrome and Associated Clinical Outcomes in Older Adults.Frontiers in medicine · 2021Article
- First insights on value-based healthcare of elders using ICHOM older person standard set reporting.BMC geriatrics · 2020Article
- PMScientific reports · 2020Article
- Comparisons Between Hypothesis- and Data-Driven Approaches for Multimorbidity Frailty Index: A Machine Learning Approach.Journal of medical Internet research · 2020Article
- Determinants and indicators of successful ageing associated with mortality: a 4-year population-based study.Aging · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is garnering increasing interest as a potential target in disability prevention. Since it is uncertain how frailty interacts with multimorbidity, urbanization, and mental health to affect disability, we investigated the epidemiology of frailty and its synergies with these factors. The study enrolled 20,898 participants aged 65 and older living in New Taipei city. All participants received face to face interview to assess frailty, multimorbidity, urban or rural residence, and mental health. Individual versus combined effects of risk factors were evaluated using the Rothman synergy index. Prevalence of frailty was 5.2% overall, 7.2% in multimorbid participants, 9.6% in rural residents, and 20.8% in those with mental disorders. Logistic regression, adjusted for age and sex, showed significant associations between disability and frailty (OR 8.5, 95% CI 6.4-11.2), multimorbidity (OR 1.3, 95% CI 1.0-1.6), urbanization (OR 1.3, 95% CI 1.0-1.7), and mental disorders (OR 7.3, 95% CI 5.6-9.5); these factors had a significant synergic effect on disability. Frailty is common in older adults and associated with disability, and was synergetic with multimorbidity, mental disorders, and residing rurally. Targeting frailty prevention and intervention needs a special attention on those vulnerable groups.
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