Evidence map›Paper›PMID 30237499›Full record

ArticleCell death & disease2018

MicroRNA-3619-5p suppresses bladder carcinoma progression by directly targeting β-catenin and CDK2 and activating p21.

Qingsong Zhang, Shuo Miao, Xihong Han, Chuanchang Li, Mengyang Zhang, Kai Cui, Tao Xiong, Zhong Chen, Chenghe Wang, Hua Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 61 citations in OpenAlex.

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  17. MicroRNAs and target molecules in bladder cancer.Medical oncology (Northwood, London, England) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Qingsong ZhangDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Shuo MiaoDepartment of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Xihong HanDepartment of Cardiology, Shouguang People's Hospital, 262700, Shouguang, Shandong, China.
Chuanchang LiDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Mengyang ZhangDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Kai CuiDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Tao XiongDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Zhong ChenDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China. chenzhongtongji@126.com.
Chenghe WangDepartment of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 200025, Shanghai, China.
Hua XuDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, 430030, Wuhan, Hubei, China.
Tongji Hospital · CNHuazhong University of Science and Technology · CNRuijin Hospital · CNShougang (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current studies indicate that microRNAs (miRNAs) are widely decreased in various tumors and function as tumor suppressors by inhibiting cancer cell proliferation, survival, invasion, and migration. The potential application of using miRNAs to predict therapeutic responses to multiple types of cancer treatment holds high promise. In current study, we demonstrate that miR-3619-5p is downregulated in bladder cancer (BCa) tissues and cells. Exogenous overexpression of miR-3619-5p in BCa cells inhibits proliferation, migration, and invasion. Moreover, a nude mouse xenograft model shows that miR-3619-5p inhibits BCa cell growth. We also demonstrate that miR-3619-5p leads to the activation of p21 by targeting its promoter in BCa cells. Enforced miR-3619-5p expression consistently leads to the downregulation of β-catenin and cyclin-dependent kinase 2 (CDK2) through predicted binding sites within the β-catenin and CDK2 3'-untranslated regions (UTRs), respectively. Moreover, β-catenin and CDK2 knockdown is able to mimic BCa cells growth and metastasis effects induced by overexpressing miR-3619-5p. We further confirm that miR-3619-5p inhibits Wnt-β-catenin signal pathway and EMT progression in BCa cells. We also found that miR-3619-5p-induced growth arrest and metastasis inhibition are p21-dependent in BCa cells. Taken together, these results confirm that miR-3619-5p plays a tumor suppressive role in BCa by interfering with cell growth and metastasis and may serve as a potential therapeutic target in BCa treatment.

Indexed as

beta CateninCell ProliferationCyclin-Dependent Kinase 2FemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMultivariate AnalysisUrinary BladderUrinary Bladder NeoplasmsWnt Signaling Pathwaybeta CateninCDK2 protein, humanCyclin-Dependent Kinase 2MicroRNAsMIRN-3619 microRNA, human

Identifiers

PMID30237499
PMCPMC6147790
OpenAlexW2890102889

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.