ArticleClinical and translational gastroenterology2018
Meconium microbiome associates with the development of neonatal jaundice.
Article in Clinical and translational gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study.Pediatric research · 2024Pooled it
- Short-term temporal variation in the early-life gut microbiota links maternal clinical phenotypes to neonatal jaundice.BMC microbiology · 2026Article
- Neonatal jaundice and the infant gut microbiome: an integrated shotgun metagenomics and bidirectional Mendelian randomization study in Xinjiang.Frontiers in microbiology · 2026Article
- The enhancing therapeutic effect of neonatal jaundice byFrontiers in microbiology · 2026Article
- Dynamic relationships between bilirubin concentrations and the gut microbiota in the neonatal period: A pilot prospective cohort study.Pediatric investigation · 2025Article
- Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota.Scientific reports · 2025Article
- Gut microbiome dysbiosis as a potential biomarker for liver metabolic disorders in in neonatal hemolytic jaundice.BMC pediatrics · 2025Article
- Gut microbiota dysbiosis in infantile cholestatic hepatopathy.Frontiers in pediatrics · 2025Article
- Temporal Investigation of the Maternal Origins of Fetal Gut Microbiota.Microorganisms · 2024Article
- Human Milk Microbiome-A Review of Scientific Reports.Nutrients · 2024Review
- Developing and evaluating a predictive model for neonatal hyperbilirubinemia based onFrontiers in pediatrics · 2024Article
- Association of breast milk microbiota and metabolites with neonatal jaundice.Frontiers in pediatrics · 2024Article
- Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis.BMC medicine · 2023Article
- The importance of the intestinal microbiota in humans and dogs in the neonatal period.Animal reproduction · 2023Review
- The relationship between gut microbiota and neonatal pathologic jaundice: A pilot case-control study.Frontiers in microbiology · 2023Article
- Metagenomic profiles of the early life microbiome of Indonesian inpatient neonates and their influence on clinical characteristics.Scientific reports · 2022Article
- Article
- Gut microbiota development in the growing dog: A dynamic process influenced by maternal, environmental and host factors.Frontiers in veterinary science · 2022Review
- Gut microbial alterations in neonatal jaundice pre- and post-treatment.Bioscience reports · 2021Article
- Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection.Iranian journal of public health · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeonatal jaundice is a common disease that affects up to 60% of newborns. Gut microbiota mediated the excretion of bilirubin from the human body. However, the relationship between early gut microbiome and development of neonatal jaundice is not fully understood. Here we sought to characterize meconium microbiome of newborns and to clarify its association with risk of neonatal jaundice.
methodsWe conducted a nested case-control study with 301 newborns providing meconium samples from 2014 to 2015. The main outcome was the development of neonatal jaundice at 42 day follow-up. 16S rRNA gene sequencing was performed to profile the meconium microbiome. LEfSe was employed to identify different features between control and case groups. Logistic regression was used to estimate the risk effect of early gut microbiome on neonatal jaundice.
resultsLogistic regression models suggested that higher ɑ-diversity was significantly associated with lower risk of jaundice in cesarean infants (OR 0.72, 95% CI 0.52-0.98), but not in infants born naturally. Higher relative abundance of Bifidobacterium pseudolongum in newborn meconium was significantly associated with lower risk of jaundice both in cesarean-born infants and in the total subjects (OR 0.24, 95% CI 0.07-0.68; OR 0.55, 95% CI 0.31-0.95, respectively). Spearman's correlations showed that relative abundance of B. pseudolongum was significantly correlated with ɑ-diversity (P < 0.01).
conclusionPreventive and treatment methods implying early gut microbiome intervention could be promising for the management of neonatal jaundice.
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