Observational studyJournal of perinatology : official journal of the California Perinatal Association2019
The impact of chlorhexidine gluconate bathing on skin bacterial burden of neonates admitted to the Neonatal Intensive Care Unit.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Antiseptic Cleansing to Reduce Vertical Transmission of Pathogens to Neonates: The NeoVT-AMR Randomized Clinical Trial.JAMA network open · 2026Trial
- Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Epidemiology and Mortality of Invasive Staphylococcus aureus Infections in Hospitalized Infants.JAMA pediatrics · 2025Article
- Impact of daily octenidine skin washing versus nonwashing on antiseptic tolerance of coagulase-negative staphylococci in two neonatal intensive care units with different skin cleansing practices.Infection prevention in practice · 2024Article
- Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial.EClinicalMedicine · 2024Article
- Article
- Antiseptic solutions for skin preparation during central catheter insertion in neonates.The Cochrane database of systematic reviews · 2023Review
- Myelin toxicity of chlorhexidine in zebrafish larvae.Pediatric research · 2023Article
- Chlorhexidine bathing in a tertiary care neonatal intensive care unit: A pilot study.PloS one · 2023Article
- Neonatal sepsis and the skin microbiome.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Longitudinal Dynamics of Skin Bacterial Communities in the Context of Staphylococcus aureus Decolonization.Microbiology spectrum · 2022Article
- Article
- Impact of 1% chlorhexidine gluconate bathing and emollient application on bacterial pathogen colonization dynamics in hospitalized preterm neonates - A pilot clinical trial.EClinicalMedicine · 2021Article
- Chlorhexidine baths in preterm infants - are we there yet?Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Molecular mechanism of antimicrobial activity of chlorhexidine against carbapenem-resistant Acinetobacter baumannii.PloS one · 2019Article
- Preoperative measures to prevent/minimize risk of surgical site infection in spinal surgery.Surgical neurology international · 2018Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the impact of chlorhexidine gluconate (CHG) bathing on skin bacterial burden in neonates. STUDY
designIn this prospective observational study, arm and groin skin bacterial growth was measured in 40 CHG-exposed and nonexposed neonates admitted to the NICU. Exposed neonates received 2% CHG baths per protocol for central line-associated bloodstream infection (CLABSI) prevention or Staphylococcus aureus decolonization.
resultsForty neonates were enrolled, 18 of whom were CHG-exposed. Mean baseline Gram-positive (GP) bacterial burden was 2.19 log CFU/ml on the arm and 1.81 log CFU/ml on the groin. Bacterial burden decreased after the first bath, but returned to baseline by 72 h. Residual skin CHG concentration declined over time, with a corresponding increase in GP bacterial burden.
conclusionsCHG bathing reduces skin bacterial burden, but burden returns to baseline after 72 h. Twice weekly CHG bathing may be inadequate to suppress skin bacterial growth in hospitalized neonates.
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Registered trials
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