ArticleScientific reports2018
Transcriptome Sequencing and Metabolism Analysis Reveals the role of Cyanidin Metabolism in Dark-red Onion (Allium cepa L.) Bulbs.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Unraveling the genetic and molecular mechanisms of anthocyanin biosynthesis and accumulation in maize kernels.Frontiers in plant science · 2026Review
- Comprehensive Characterization of Metabolites in Multiplier Onion Bulbs and Identification of Regulatory Genes for Nutritional Improvement.Foods (Basel, Switzerland) · 2025Article
- AlliumDB: a central portal for comparative and functional genomics inHorticulture research · 2024Article
- Chromosome-level genomes of three key Allium crops and their trait evolution.Nature genetics · 2023Article
- Comprehensive analysis of metabolome and transcriptome reveals the mechanism of color formation in different leave of Loropetalum Chinense var. Rubrum.BMC plant biology · 2023Article
- Extraction of Antioxidant Compounds from Onion Bulb (Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Accumulation of Anthocyanidins Determines Leaf Color of Liquidambar Formosana as Revealed by Transcriptome Sequencing and Metabolism Analysis.Current issues in molecular biology · 2022Article
- Onion anthocyanins: Extraction, stability, bioavailability, dietary effect, and health implications.Frontiers in nutrition · 2022Review
- The bHLH transcription factor AcB2 regulates anthocyanin biosynthesis in onion (Horticulture research · 2022Article
- Development of Optimized Ultrasound-Assisted Extraction Methods for the Recovery of Total Phenolic Compounds and Anthocyanins from Onion Bulbs.Antioxidants (Basel, Switzerland) · 2021Article
- Transcriptome analysis and genetic diversity ofMitochondrial DNA. Part B, Resources · 2021Article
- Transcriptome and phytohormone changes associated with ethylene-induced onion bulb dormancy.Postharvest biology and technology · 2020Article
- Mechanism of Allium Crops Bulb Enlargement in Response to Photoperiod: A Review.International journal of molecular sciences · 2020Review
- Omics approaches inPeerJ · 2020Article
- Comparative transcriptome analyses in contrasting onion (Allium cepa L.) genotypes for drought stress.PloS one · 2020Article
- Assessing Anthocyanin Biosynthesis in Solanaceae as a Model Pathway for Secondary Metabolism.Genes · 2019Article
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Onion (Allium cepa L.) is an important bulbous vegetable crop that possesses important properties related to health as well as extraordinary colors. Naturally white onion bulbs were used in this study to reveal the complex metabolic mechanisms that underlie phenotypic traits, especially bulb pigmentation. Six libraries (three dark-red and three white) were constructed and analyzed to elucidate differences in cyanidin (Cy) metabolism between dark-red and white onion bulbs. Libraries were screened using RNA-sequencing (RNA-seq) to reveal the differentially expressed genes (DEGs) involved in anthocyanin biosynthesis at the transcriptional level. Comparison with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database shows that a total of 27 unigenes participate in onion anthocyanin biosynthesis and 16 DEGs perform critical roles in flavonoid biosynthesis. Expression patterns of color-related flavonoid compounds associated with the onion anthocyanin biosynthesis pathway (ABP) show that flavonoid 3',5'-hydroxylase (F3'5'H) and dihydroflavonol 4-reductase (DFR) genes play crucial roles in the biosynthesis of dark-red bulbs, the expression levels of flavonol synthase (FLS) and DFR genes may act to block blue pigmentation, and the loss of Cy from white onion bulbs might explain multibranching in the synthesis of this compound. Positive variation in the F3'5'H/F3'H ratio also affects onion bulb color diversity. The transcriptome presented here provides a basis for future onion molecular breeding based on variations in the diversity of ornamental plant pigmentation.
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