Evidence map›Paper›PMID 30237305›Full record

Trial reportThe European respiratory journal2018

Safety of biweekly α

Timm Greulich, Jan Chlumsky, Marion Wencker, Oliver Vit, Michael Fries, Thomas Chung, Amgad Shebl, Claus Vogelmeier, Kenneth R Chapman, Noel G McElvaney and 1 more

Registry-linked trialAbstract readLetterRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07125664 (A Two-center, Randomized, Double-blind, Placebo-controlled Study of Intravenous Plasma-purified Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07125664 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Two-center, Randomized, Double-blind, Placebo-controlled Study of Intravenous Plasma-purified Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)

TypeinterventionalSponsorFondazione IRCCS Policlinico San Matteo di PaviaRan2025 to 2027Enrolled36ConditionsAcute Exacerbation Chronic Obstructive Pulmonary DiseaseArmsalpha1-proteinase inhibitor, produced from the plasma of human donors (Prolastin 1000 mg, powder and solvent for solution for infusion), Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. New Patient-Centric Approaches to the Management of Alpha-1 Antitrypsin Deficiency.International journal of chronic obstructive pulmonary disease · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Timm GreulichDept of Medicine, Respiratory and Critical Care Medicine, Philipps-University Marburg, Member of the German Center for Lung Diseases (DZL), Marburg, Germany.
Jan ChlumskyDept of Pulmonary Diseases, Charles University, Prague, Czech Republic.
Marion Wenckerconresp, Loerzweiler, Germany.
Oliver VitClinical Research and Development, CSL Behring, Bern, Switzerland.
Michael FriesClinical Strategy and Development, CSL Behring, King of Prussia, PA, USA.
Thomas ChungStatistics Dept, CSL Behring, King of Prussia, PA, USA.
Amgad SheblGlobal Clinical Safety and Pharmacovigilance, CSL Behring, Marburg, Germany.
Claus VogelmeierDept of Medicine, Respiratory and Critical Care Medicine, Philipps-University Marburg, Member of the German Center for Lung Diseases (DZL), Marburg, Germany.
Kenneth R ChapmanDept of Medicine, University of Toronto, Toronto, ON, Canada.
Noel G McElvaneyIrish Centre for Genetic Lung disease, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.
RAPID Trial Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adultalpha 1-Antitrypsinalpha 1-Antitrypsin DeficiencyFemaleHumansInfusions, IntravenousLungMaleMiddle AgedPulmonary EmphysemaTreatment Outcomealpha 1-Antitrypsin

Identifiers

PMID30237305
PMCPMC6557539

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.