Evidence map›Paper›PMID 30237299›Full record

ArticleAJNR. American journal of neuroradiology2018

Cerebrovascular Reactivity during Prolonged Breath-Hold in Experienced Freedivers.

V C Keil, L Eichhorn, H J M M Mutsaerts, F Träber, W Block, B Mädler, K van de Ven, J C W Siero, B J MacIntosh, J Petr and 3 more

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Cerebral hemodynamic and systemic physiological changes in trained freedivers completing sled-assisted dives to two different depths.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  4. Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Article
  6. Article
  7. Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

V C KeilFrom the Departments of Radiology (V.C.K., F.T., W.B., H.H.S., E.H.) vera.keil@ukbonn.de.ORCID 0000-0001-8699-3506
L EichhornAnesthesiology and Intensive Care Medicine (L.E.).ORCID 0000-0002-9769-0639
H J M M MutsaertsDepartment of Radiology (H.J.M.M.M.), Academic Medical Center, Amsterdam, the Netherlands.ORCID 0000-0003-0894-0307
F TräberFrom the Departments of Radiology (V.C.K., F.T., W.B., H.H.S., E.H.).ORCID 0000-0002-9713-3445
W BlockFrom the Departments of Radiology (V.C.K., F.T., W.B., H.H.S., E.H.).ORCID 0000-0003-3095-6356
B MädlerPhilips GmbH (B.M), Bonn, Germany.ORCID 0000-0002-1465-2961
K van de VenPhilips Healthcare (K.v.d.V.), Best, the Netherlands.ORCID 0000-0002-2751-6213
J C W SieroDepartment of Radiology (H.J.M.M.M., J.C.W.S.), University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0001-5079-2868
B J MacIntoshSunnybrook Research Institute (H.J.M.M.M., B.J.M.), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-7300-2355
J PetrHelmholtz Center Dresden-Rossendorf, Institute for Radiopharmaceutic Cancer Research (J.P.), PET Center, Dresden-Rossendorf, Germany.ORCID 0000-0002-3201-6002
R FimmersInstitut für Medizinische Biometrie, Informatik und Epidemiologie (R.F.), University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-7485-6803
H H SchildFrom the Departments of Radiology (V.C.K., F.T., W.B., H.H.S., E.H.).ORCID 0000-0003-4264-0121
E HattingenFrom the Departments of Radiology (V.C.K., F.T., W.B., H.H.S., E.H.).ORCID 0000-0002-8392-9004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeExperienced freedivers can endure prolonged breath-holds despite severe hypoxemia and are therefore ideal subjects to study apnea-induced cerebrovascular reactivity. This multiparametric study investigated CBF, the spatial coefficient of variation as a correlate of arterial transit time and brain metabolism, dynamics during prolonged apnea. MATERIALS AND

methodsFifteen male freedivers (age range, 20-64 years; cumulative previous prolonged breath-holds >2 minutes and 30 seconds: 4-79,200) underwent repetitive 3T pseudocontinuous arterial spin-labeling and

resultsThe spatial coefficient of variation of CBF (by arterial spin-labeling) decreased during the early breath-hold phase (-30.0%,

conclusionsThis study revealed that the cerebral energy metabolism of trained freedivers withstands severe hypoxic hypercarbia in prolonged breath-hold due to a complex cerebrovascular hemodynamic response.

Indexed as

Breath HoldingAdultBrainCerebrovascular CirculationDivingHumansHypercapniaHypoxiaMaleMiddle AgedSpin LabelsYoung AdultSpin Labels

Identifiers

PMID30237299
PMCPMC7410726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.