Evidence map›Paper›PMID 30237269›Full record

ArticleHaematologica2019

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp.

Maria G Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner

Open access · goldAbstract readCase ReportsLetter
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Open biology · 2025
    Review
  4. High-throughput methods for cardiac cellular electrophysiology studies: the road to personalized medicine.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Altered CaCells · 2021
    Article
  16. Article
  17. Article
  18. Mechanical Stress Induces CaInternational journal of molecular sciences · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Maria G RotordamSaarland University, Theoretical Medicine and Biosciences, Homburg/Saar, Germany.
Elisa FermoUOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Nadine BeckerNanion Technologies GmbH, Munich, Germany.
Wilma BarcelliniUOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Andrea BrüggemannNanion Technologies GmbH, Munich, Germany.
Niels FertigNanion Technologies GmbH, Munich, Germany.
Stéphane EgéeSorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, Roscoff Cedex, France.
Markus RapediusNanion Technologies GmbH, Munich, Germany Markus.Rapedius@nanion.de paola.bianchi@policlinico.mi.it lars_kaestner@me.com.
Paola BianchiUOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy Markus.Rapedius@nanion.de paola.bianchi@policlinico.mi.it lars_kaestner@me.com.
Lars KaestnerSaarland University, Theoretical Medicine and Biosciences, Homburg/Saar, Germany Markus.Rapedius@nanion.de paola.bianchi@policlinico.mi.it lars_kaestner@me.com.
Nanion (Germany) · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITCentre National de la Recherche Scientifique · FRSaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gain of Function MutationAdultAnemia, Hemolytic, CongenitalErythrocytesHigh-Throughput Screening AssaysHumansIon ChannelsMalePatch-Clamp TechniquesPrognosisIon ChannelsPIEZO1 protein, human

Identifiers

PMID30237269
PMCPMC6518891
OpenAlexW2889579569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.