ArticleDevelopment (Cambridge, England)2018
Characterization of the ventricular-subventricular stem cell niche during human brain development.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium.bioRxiv : the preprint server for biology · 2026Article
- Fibrinogen as a Driver of Oxidative Stress and Apoptosis in the Fetal Brain After Maternal Influenza.Research square · 2026Article
- Isolation of postnatal human neural stem cells.bioRxiv : the preprint server for biology · 2026Article
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Communications biology · 2026Article
- Morphological patterns of fetal lateral ventricular border irregularities: descriptive study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Biallelic TruncatingInternational journal of molecular sciences · 2026Review
- Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids.EMBO reports · 2026Article
- Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans-Similarities and Differences from Animal Models.Journal of molecular neuroscience : MN · 2025Review
- Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model.Nature communications · 2025Article
- Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.Biology of sex differences · 2025Article
- The subventricular zone structure, function and implications for neurological disease.Genes & diseases · 2025Review
- Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis.Annals of neurology · 2025Article
- Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.Cell reports · 2025Article
- Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia.Fluids and barriers of the CNS · 2025Article
- Significance of birth in the maintenance of quiescent neural stem cells.Science advances · 2025Article
- Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus.Fluids and barriers of the CNS · 2024Article
- Paediatric hydrocephalus.Nature reviews. Disease primers · 2024Review
- RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation.Schizophrenia (Heidelberg, Germany) · 2024Article
- Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice.PLoS biology · 2024Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
Human brain development proceeds via a sequentially transforming stem cell population in the ventricular-subventricular zone (V-SVZ). An essential, but understudied, contributor to V-SVZ stem cell niche health is the multi-ciliated ependymal epithelium, which replaces stem cells at the ventricular surface during development. However, reorganization of the V-SVZ stem cell niche and its relationship to ependymogenesis has not been characterized in the human brain. Based on comprehensive comparative spatiotemporal analyses of cytoarchitectural changes along the mouse and human ventricle surface, we uncovered a distinctive stem cell retention pattern in humans as ependymal cells populate the surface of the ventricle in an occipital-to-frontal wave. During perinatal development, ventricle-contacting stem cells are reduced. By 7 months few stem cells are detected, paralleling the decline in neurogenesis. In adolescence and adulthood, stem cells and neurogenesis are not observed along the lateral wall. Volume, surface area and curvature of the lateral ventricles all significantly change during fetal development but stabilize after 1 year, corresponding with the wave of ependymogenesis and stem cell reduction. These findings reveal normal human V-SVZ development, highlighting the consequences of disease pathologies such as congenital hydrocephalus.
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