ArticleDevelopment (Cambridge, England)2018
Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Lessons from In Utero and Postnatal Exposure to Pesticide DDT: Mechanisms of Chromaffin Cell Vulnerability and Altered Catecholamine Homeostasis.International journal of molecular sciences · 2026Review
- Schwann Cell Mapping and Characterization in Bone of Different Embryonic Origins.bioRxiv : the preprint server for biology · 2026Article
- New Concepts of Regeneration and Renewal of Adrenal Chromaffin Cells.International journal of molecular sciences · 2025Review
- Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification.Histochemistry and cell biology · 2025Review
- SOX2Nature communications · 2025Article
- Motor innervation directs the correct development of the mouse sympathetic nervous system.Nature communications · 2024Article
- Neural crest and sons: role of neural crest cells and Schwann cell precursors in development and gland embryogenesis.Frontiers in cell and developmental biology · 2024Review
- Controls of Central and Peripheral Blood Pressure and Hemorrhagic/Hypovolemic Shock.Journal of clinical medicine · 2023Review
- Schwann cell precursors represent a neural crest-like state with biased multipotency.The EMBO journal · 2022Article
- Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics.Frontiers in endocrinology · 2022Article
- Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.Nature genetics · 2021Article
- Neuronal lineages derived from the nerve-associated Schwann cell precursors.Cellular and molecular life sciences : CMLS · 2021Review
- Development of the Autonomic Nervous System: Clinical Implications.Seminars in neurology · 2020Review
- Development of extrinsic innervation in the abdominal intestines of human embryos.Journal of anatomy · 2020Article
- Pheochromocytomas and Paragangliomas: New Developments with Regard to Classification, Genetics, and Cell of Origin.Cancers · 2019Review
- Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia.Frontiers in molecular neuroscience · 2019Article
- Hijacking of Embryonic Programs by Neural Crest-Derived Neuroblastoma: From Physiological Migration to Metastatic Dissemination.Frontiers in molecular neuroscience · 2019Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla and how they become connected to central nervous system-derived preganglionic sympathetic neurons remain largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3 proteins serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.