ArticleNeurobiology of aging2018
Age-related decline in cognitive flexibility in female chimpanzees.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Retinal Layer Changes With Aging and Cognitive Decline in Rhesus Macaques.Translational vision science & technology · 2026Article
- A Comparative Study of Aging and Cortical Folding in Chimpanzees and Olive Baboons.American journal of primatology · 2026Article
- Smart Ungulates: What Sheep and Goats' Performances in a Reversed-Reward Contingency Task Tell Us About the Evolution of Cognitive Flexibility.Ecology and evolution · 2026Article
- Article
- Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution.Inflammation and regeneration · 2025Review
- The ecology of ageing in wild societies: linking age structure and social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Review
- Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Fear extinction is impaired in aged rats.GeroScience · 2024Article
- Assessment of Cognitive Flexibility in Jordanian Diabetic Patients by Wisconsin Card Sorting and Trail Making Tests: Implications with Demographic, Anthropometric and Therapeutic Variables.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Amyloid-β Pathology Is the Common Nominator Proteinopathy of the Primate Brain Aging.Journal of Alzheimer's disease : JAD · 2024Review
- Age differences in cortical thickness and their association with cognition in chimpanzee (Pan troglodytes).Neurobiology of aging · 2023Article
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.Neurobiology of aging · 2023Article
- Article
- The shifting shelf task: a new, non-verbal measure for attentional set shifting.Proceedings. Biological sciences · 2023Article
- Interaction of cholinergic disruption and age on cognitive flexibility in rats.Experimental brain research · 2022Article
- The origins of cognitive flexibility in chimpanzees.Developmental science · 2022Article
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- Social ageing: exploring the drivers of late-life changes in social behaviour in mammals.Biology letters · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Data on cognitive aging in chimpanzees are extremely sparse, yet can provide an invaluable phylogenetic perspective, especially because Alzheimer disease (AD)-like neuropathology has recently been described in the oldest chimpanzee brains. This finding underscores the importance of data on cognitive aging in this fellow hominin, our closest biological relative. We tested 30 female chimpanzees, 12-56 years old, on a computerized analog of the Wisconsin Card Sort test. This test assesses cognitive flexibility, which is severely impaired in normal aging and AD. Subjects selected stimuli according to color or shape; the rewarded dimension (i.e., color or shape) switched without warning and the chimpanzee had to adapt her responses accordingly. We found that increasing age was associated with an increased number of perseverative errors and an increased number of trials to reach criterion in each switching dimension. The number of aborted trials was similar across age groups. These data show that similar to humans, chimpanzees show a clear age-related decline in cognitive flexibility that is already observed at middle age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.