ArticleAmerican journal of ophthalmology2019
What Is the Amount of Visual Field Loss Associated With Disability in Glaucoma?
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Structural Damage, Visual Field Loss, and Quality of Life in Optic Disc Drusen: A Case-Control Study with Integrated Data-Driven Phenotypes.Journal of clinical medicine · 2025Article
- Ocular retinal findings in asymptomatic patients with antiphospholipid syndrome secondary to systemic lupus erythematosus.Clinical rheumatology · 2023Article
- Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss.Ophthalmology · 2023Observational
- Subjective well-being patterns in older men and women without someone to confide in: a latent class analysis approach.Frontiers in public health · 2023Article
- Electrical neurostimulation in glaucoma with progressive vision loss.Bioelectronic medicine · 2022Article
- Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.American journal of ophthalmology · 2021Article
- Artificial Intelligence Mapping of Structure to Function in Glaucoma.Translational vision science & technology · 2020Article
- Association of an Objective Structural and Functional Reference Standard for Glaucoma with Quality of Life Outcomes.Ophthalmology. GlaucomaArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo propose a new methodology for classifying patient-reported outcomes in glaucoma and for quantifying the amount of visual field damage associated with disability in the disease.
designCross-sectional study.
methodsA total of 263 patients with glaucoma were included. Vision-related disability was assessed by the National Eye Institute Visual Function Questionnaire (NEI VFQ-25). A latent class analysis (LCA) model was applied to analyze NEI VFQ-25 data and patients were divided into mutually exclusive classes according to their responses to the questionnaires. Differences in standard automated perimetry (SAP) mean deviation (MD) and integrated binocular mean sensitivity (MS) values between classes were investigated. The optimal number of classes was defined based on goodness-of-fit criteria, interpretability, and clinical utility.
resultsThe model with 2 classes, disabled and nondisabled, had the best fit with an entropy of 0.965, indicating excellent separation of classes. The disabled group had 48 (18%) patients, whereas 215 (82%) patients were classified as nondisabled. The average MD of the better eye in the disabled group was -5.98 dB vs -2.51 dB in the nondisabled group (P < .001). For the worse eye, corresponding values were -13.36 dB and -6.05 dB, respectively (P < .001).
conclusionApplication of an LCA model allowed categorization of patient-reported outcomes and quantification of visual field levels associated with disability in glaucoma. A damage of approximately -6 dB for SAP MD, indicating relatively early visual field loss, may already be associated with significant disability if occurring in the better eye.
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