ArticleJournal of diabetes and its complications2018
The differential impact of adverse childhood experiences in the development of pre-diabetes in a longitudinal cohort of US adults.
Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Sexual violence and cardiovascular disease risk: A systematic review and meta-analysis.Maturitas · 2021Pooled it
- A Double-Hit Model of Early-Life Stress and High-Fat Feeding Reveals Enhanced Exocrine Pancreatic Remodeling.Biology · 2026Article
- Psychosocial Disadvantage During Childhood and Midlife Health: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Adverse Childhood Experiences and Burnout in Athletic Trainers: An Exploratory Study.Journal of athletic training · 2023Article
- Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population.SSM - population health · 2023Article
- Can adverse childhood experiences predict chronic health conditions? Development of trauma-informed, explainable machine learning models.Frontiers in public health · 2023Article
- Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers.Biology of sex differences · 2022Article
- Association of childhood physical and sexual abuse with arthritis in adulthood: Findings from a population-based study.Preventive medicine reports · 2021Article
- Does family communication moderate the association between adverse childhood experiences and emotional and behavioural problems?BMC public health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundACEs have a dose-response relationship with diabetes. The relationship between ACEs and pre-diabetes is not well known and may represent an effective area for prevention efforts.
methodsData from 1054 participants from two waves of the longitudinal MIDUS study were used. Multivariate general linear regression models assessed the relationship between ACEs and biomarker outcomes. Correlation tests and mediation models investigated the relationship between ACE and pre-diabetes.
resultsIndividuals reporting ACEs were statistically significantly more likely to have higher BMI (1.13 (0.34-1.92)), higher waist circumference (2.74 (0.72-4.76)), elevated blood fasting insulin levels (2.36 (0.71-4.02)) and higher insulin resistance (HOMA-IR (0.57 (0.08-1.06)). BMI/waist circumference and insulin resistance did not maintain independent relationships with ACEs once HOMA-IR was included in the dichotomized ACE model (p = 0.05 and p = 0.06, respectively), suggesting the relationship between BMI and ACEs may be mediated by insulin resistance.
conclusionsThese results represent one of the first studies to examine the differential impact of ACEs on a diverse set of clinical pre-diabetes measures. Findings suggest sexual and physical abuse, and financial strain during childhood are important factors associated with higher risk for pre-diabetes, and should be considered during intervention development.
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