ArticleEBioMedicine2018
Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 22 citations in OpenAlex.
- Risk factors for local recurrence and metastasis of eyelid sebaceous carcinoma after complete excision: A large cohort study in Japan.Indian journal of ophthalmology · 2026Article
- Regional Lymph Node Metastasis in Sebaceous Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.Cancers · 2026Review
- Clinical presentation and prognostic factors of eyelid sebaceous carcinoma.Japanese journal of ophthalmology · 2025Article
- Recurrence in Eyelid Sebaceous Carcinoma: A Multicentric Study of 418 Patients.Investigative ophthalmology & visual science · 2024Article
- Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.Archives of dermatological research · 2023Review
- Development and validation of a nomogram to predict the recurrence of eyelid sebaceous gland carcinoma.Cancer medicine · 2023Article
- Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma.The British journal of ophthalmology · 2023Article
- A nomogram for predicting overall survival of patients with sinonasal melanoma: A population-based study.Laryngoscope investigative otolaryngology · 2022Article
- MicroRNA-3907 promotes the proliferation and migration of sebaceous gland carcinoma of the eyelid by targeting thrombospondin 1.Oncology letters · 2021Article
- Upper eyelid reconstruction using a combination of a nasal septal chondromucosal graft and a Fricke flap: a case report.Archives of craniofacial surgery · 2021Article
- A NADE nomogram to predict the probability of 6-month unfavorable outcome in Chinese patients with ischemic stroke.BMC neurology · 2019Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundThe prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC.
methodsThis study included 238 consecutive patients with eyelid SC. All eligible patients were followed up for metastasis and mortality. The predictors of tumor-related survival were explored by Cox analyses. A prognostic nomogram was developed and validated using bootstrap resampling. The predictive accuracy and discriminative ability were compared between the nomogram and the Tumor, Node, Metastasis (TNM) staging system.
findingsAfter a median follow-up period of 55.5 months, 27 (11.3%) patients died of metastatic SC, with a median survival time of 48.0 months. The 5-year and 10-year tumor-related survival rates were 88.1% and 77.9%, respectively. Orbital involvement (HR: 3.11, p = .022), the greatest tumor basal diameter (HR: 1.06, p = .003), the presence of pagetoid spread (HR: 2.90, p = .017), and having lymph node metastasis at initial diagnosis (HR: 13.66, p < .001) were independent risk factors for tumor-related death. A nomogram integrating these 4 factors was developed with a C-index of 0.887, which is significantly better than that of the TNM staging system (p = .002). The risk groups stratified by nomogram scores (p < .001 (low vs intermediate risk); p = .001 (intermediate vs high risk)) displayed better discrimination ability than TNM staging (T1 vs T2: p = .358; T2 vs T3: p = .171; T3 vs T4: p < .001) in patients at an early stage.
interpretationThe prognosis of Chinese patients with eyelid SC has improved over the last 3 decades, and it is comparable to that of patients from other countries. This nomogram provides more accurate individualized estimates of survival for eyelid SC patients and may guide clinicians in their therapeutic decisions.
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