ArticleDevelopmental biology2018
Transcriptome profiling of the cardiac neural crest reveals a critical role for MafB.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Regulatory logic underlying neural crest contributions to the head versus the heart.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tissue-specific lncRNA GATA6-AS1 and its ortholog Moshe as essential regulators of aortic valve development.BMB reports · 2025Article
- Exploring the origins of neurodevelopmental proteasomopathies associated with cardiac malformations: are neural crest cells central to certain pathological mechanisms?Frontiers in cell and developmental biology · 2024Article
- Androgen-regulatediScience · 2022Article
- Article
- Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during development.EMBO reports · 2021Article
- The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos.Development (Cambridge, England) · 2021Article
- Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies.Cellular and molecular neurobiology · 2021Review
- Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells: Methods, Applications, and Considerations.Circulation research · 2021Review
- A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation.PLoS genetics · 2021Article
- Cardiac Progenitor Cells.Advances in experimental medicine and biology · 2021Review
- The heart of the neural crest: cardiac neural crest cells in development and regeneration.Development (Cambridge, England) · 2020Review
- Bimodal function of chromatin remodelereLife · 2020Article
- Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects.Developmental cell · 2020Article
- Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes.Journal of cardiovascular development and disease · 2020Article
- Network architecture and regulatory logic in neural crest development.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Early chromatin shaping predetermines multipotent vagal neural crest into neural, neuronal and mesenchymal lineages.Nature cell biology · 2019Article
- Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish.eLife · 2019Article
- Transcriptome dataset of trunk neural crest cells migrating along the ventral pathway of chick embryos.Data in brief · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The cardiac neural crest originates in the caudal hindbrain, migrates to the heart, and contributes to septation of the cardiac outflow tract and ventricles, an ability unique to this neural crest subpopulation. Here we have used a FoxD3 neural crest enhancer to isolate a pure population of cardiac neural crest cells for transcriptome analysis. This has led to the identification of transcription factors, signaling receptors/ligands, and cell adhesion molecules upregulated in the early migrating cardiac neural crest. We then functionally tested the role of one of the upregulated transcription factors, MafB, and found that it acts as a regulator of Sox10 expression specifically in the cardiac neural crest. Our results not only reveal the genome-wide profile of early migrating cardiac neural crest cells, but also provide molecular insight into what makes the cardiac neural crest unique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.