ArticleNeuron2018
Kappa Opioid Receptor Distribution and Function in Primary Afferents.
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Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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90citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 2% of its field
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- The efficacy and safety of difelikefalin for pruritus in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.Renal failure · 2024Pooled it
- HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials.Nature communications · 2025Trial
- κ-Opioid Receptor Plasma Levels Are Associated With Sex and Diagnosis of Major Depressive Disorder But Not Response to Ketamine.Journal of clinical psychopharmacologyTrial
- Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response.Behavioural pharmacology · 2026Article
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- RGS6 regulates Kappa opioid receptor-mediated antinociceptive behaviors.Neuropharmacology · 2026Article
- Article
- Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human.bioRxiv : the preprint server for biology · 2026Article
- Development and Biological Characterization of Fluorescent Dynorphins for the Visualization of Kappa Opioid Receptors.Journal of medicinal chemistry · 2026Article
- Animal Models of Prenatal Opioid Exposure: Insights into Impaired Neurodevelopment.Advances in experimental medicine and biology · 2026Review
- A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.PloS one · 2026Article
- κ-Opioid Receptor Agonists as Robust Pain-Modulating Agents: Mechanisms and Therapeutic Potential in Pain Modulation.Journal of clinical medicine · 2025Review
- Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition.Molecular brain · 2025Article
- KOR agonists for the treatment and/or prevention of opioid use disorder and cocaine use disorder.Pharmacology, biochemistry, and behavior · 2025Review
- Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia-reperfusion-induced acute kidney injury.BMC nephrology · 2025Article
- Pruritus in Uremic Patients: Approaches to Alleviating a Common Symptom in Chronic Kidney Disease.Life (Basel, Switzerland) · 2025Review
- Article
- Hair Loss in a Hemodialysis Patient after Repetitive Use of the Antipruritic Drug Nalfurafine: Implications of Impaired Angiogenesis for Hair Loss.Internal medicine (Tokyo, Japan) · 2025Article
- Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.The EMBO journal · 2025Article
- Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics.ACS medicinal chemistry letters · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 3 institutions in 2 countries.
Lindsey M SnyderDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Michael C ChiangDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Emanuel Loeza-AlcocerDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yu OmoriDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Junichi HachisukaDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Tayler D SheahanDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jenna R GaleDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Peter C AdelmanDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Elizabeth I SypekDepartment of Anesthesiology, Perioperative, and Pain Medicine, Department of Molecular and Cellular Physiology, and Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Stephanie A FultonDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Robert L FriedmanDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Margaret C WrightDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Melissa Giraldo DuqueDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yeon Sun LeeDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Zeyu HuDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Huizhen HuangDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Tsinghua University School of Medicine Beijing, Beijing 100084, China.
Xiaoyun CaiDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kimberly A MeerschaertDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Vidhya NagarajanDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Toshiro HiraiDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Gregory ScherrerDepartment of Anesthesiology, Perioperative, and Pain Medicine, Department of Molecular and Cellular Physiology, and Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA; New York Stem Cell Foundation-Robertson Investigator, Stanford University, Palo Alto, CA 94304, USA.
Daniel H KaplanDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Frank PorrecaDepartment of Pharmacology, University of Arizona, Tucson, AZ 85719, USA.
Brian M DavisDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Michael S GoldDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: msg22@pitt.edu.
H Richard KoerberDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: rkoerber@pitt.edu.
Sarah E RossDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: saross@pitt.edu.
University of Pittsburgh · USNeurosciences Institute · USUniversity of Arizona · US
Funding
Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2MPredoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0MInvestigating the Neural Circuits of ItchR01AR063772 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI H Richard Koerber, Sarah Elizabeth Ross · 2013 to 2026
$6.9MAnatomical-Functional Mapping of Enteric Neural CircuitsOT2OD023859 · OD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HOWARD, MARTHE J · 2016 to 2019
$6.9MPeripheral Nerve Regeneration and Sensory Neuron PlasticityR01NS023725 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD · 1986 to 2017
$5.9MMolecular genetic dissection of the spinal microcircuits of wind-upR01NS096705 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD, ROSS, SARAH ELIZABETH · 2016 to 2025
$5.1MImmune Functions of Cutaneous NociceptorsR01AR071720 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel H Kaplan · 2017 to 2026
$4.1MRegulated Activation of Latent-TGFb Determines Leukocyte Occupancy of the Epidermal NicheR01AR060744 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2011 to 2020
$4.0MTraining in Mechanisms and Clinical Presentation of PainT32NS073548 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jami Lynn Saloman, BRADLEY K. TAYLOR · 2012 to 2026
$3.1MCharacterization of epithelial-neural communicationR01AR069951 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERS, KATHRYN MARIE, DAVIS, BRIAN M · 2016 to 2020
$2.8MBrain reward circuits and relief of ongoing painR01DA034975 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK · 2013 to 2017
$2.8MCortical opioid dysfunction in chronic painR01DA041809 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK, WANG, ZAIJIE JIM · 2016 to 2020
$2.7MNIAMS NIH HHS R01 AR060744NIAMS NIH HHS R01 AR063772NIAMS NIH HHS R01 AR069951NIAMS NIH HHS R01 AR071720NIAMS NIH HHS R21 AR064445NIDA NIH HHS K99 DA031777NIDA NIH HHS R00 DA031777NIDA NIH HHS R01 DA034975NIDA NIH HHS R01 DA041809NIDA NIH HHS R01 DA044481NIDDK NIH HHS R01 DK107966NIH HHS OT2 OD023859NIMH NIH HHS T32 MH020016NINDS NIH HHS F30 NS096860NINDS NIH HHS F31 NS092146NINDS NIH HHS R01 NS023725NINDS NIH HHS R01 NS083347NINDS NIH HHS R01 NS096705NINDS NIH HHS R56 NS023725NINDS NIH HHS T32 NS007433NINDS NIH HHS T32 NS073548
Abstract
Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show that KOR is expressed in several populations of primary afferents: a subset of peptidergic sensory neurons, as well as low-threshold mechanoreceptors that form lanceolate or circumferential endings around hair follicles. We find that KOR acts centrally to inhibit excitatory neurotransmission from KOR-cre afferents in laminae I and III, and this effect is likely due to KOR-mediated inhibition of Ca
Indexed as
AnimalsAxonsMiceMice, TransgenicNeuronsNeurons, AfferentNociceptorsPainPain ManagementReceptors, Opioid, kappaSignal TransductionReceptors, Opioid, kappadorsal root gangliaDRGdynorphinhumanitchmousenalfurafineOprk1painprimary afferents
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.