Evidence map›Paper›PMID 30236218›Full record

ArticleDeutsches Arzteblatt international2018

Cancers Due to Infection and Selected Environmental Factors.

Thomas Gredner, Gundula Behrens, Christian Stock, Hermann Brenner, Ute Mons

Abstract read
In one paragraph

Article in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lung cancer mortality attributable to residential radon in Germany.Radiation and environmental biophysics · 2024
    Article
  7. Observational
  8. Review
  9. Review
  10. Lung cancer mortality attributable to residential radon: a systematic scoping review.Journal of exposure science & environmental epidemiology · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. [Prevention of HPV-induced diseases by prophylactic vaccination].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Review
  16. Anal dysplasia and anal cancer. English version.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020
    Review
  17. Review
  18. Review
  19. [Anal dysplasia and anal cancer].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020
    Review
  20. Cancer Prevention Europe.Molecular oncology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thomas Gredner* Joint last authors; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty Heidelberg, University of Heidelberg, Heidelberg; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg; Cancer Prevention Unit, German Cancer Research Center (DKFZ), Heidelberg.
Gundula Behrens
Christian Stock
Hermann Brenner
Ute Mons

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCausal relationships with the occurrence of cancer have been established for a number of infections and environmental risk factors.

methodsNumbers and proportions (population-attributable fractions, PAF) of cancer cases attributable to these factors in Germany were calculated by sex and age groups for ages 35 to 84 years based on population projections, national cancer incidence, exposure data, and published risk estimates.

resultsFor 2018, more than 17 600 cancer cases (4.0% of all incident cancers) were estimated to be attributable to infections. The largest contributions come from Helicobacter pylori (n = 8764) and human papillomavirus (n = 7669) infections. Infection with hepatitis B and C, human immunodeficiency virus, and human herpesvirus 8 were estimated to cause 983 cases, 144 cases, and 116 cases, respectively. More than 5400 cancer cases (1.2% of all incident cancers) were estimated to be attributable to selected environmental factors, of which the largest contributor is indoor radon (n = 3185), followed by particulate matter (n = 1049), sunbed use (n = 892), and secondhand smoke (n = 309).

conclusionOf all cancers expected in 2018 in Germany, at least 5% are attributable to potentially avoidable infections and environmental factors. Further research should be directed towards more comprehensive identification and quantification of environmental risks as a basis for targeted cancer prevention.

Indexed as

AdultAgedAged, 80 and overEnvironmental ExposureFemaleGermanyHelicobacter InfectionsHelicobacter pyloriHepatitisHumansInfectionsMaleMiddle AgedNeoplasmsPapillomavirus InfectionsPrevalence

Identifiers

PMID30236218
PMCPMC6206252

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.