Evidence map›Paper›PMID 30236188›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018

Quality of care in childhood tuberculosis diagnosis at primary care clinics in Kampala, Uganda.

S Kizito, A Katamba, C Marquez, P Turimumahoro, I Ayakaka, J L Davis, A Cattamanchi

Abstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Pediatric Tuberculosis Diagnostics: Present and Future.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  8. Review
  9. Predictors of evaluation in child contacts of TB patients.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S KizitoSchool of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
A KatambaSchool of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
C MarquezDivision of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California.
P TurimumahoroSchool of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
I AyakakaSchool of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
J L DavisPulmonary, Critical Care, & Sleep Medicine Section, School of Medicine and Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, Connecticut.
A CattamanchiDivision of Pulmonary and Critical Care Medicine and Center for Vulnerable Populations, Zuckerberg San Francisco General Hospital, and Curry International Tuberculosis Center, University of California San Francisco, San Francisco, California, USA.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
TB and Other Pulmonary Complications of AIDS Research Training ProgramD43TW009607 · FIC · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN, KATAMBA, ACHILLES · 2013 to 2022
$3.2M
Childhood Tuberculosis Infection Among School-Age Children in Rural UgandaK23AI118592 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARQUEZ, CARINA · 2015 to 2019
$946k
FIC NIH HHS D43 TW009607FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338NIAID NIH HHS K23 AI118592
6 · The paper itself

Abstract

objectiveTo assess the quality of routine childhood tuberculosis (TB) evaluation in Kampala, Uganda. SETTING AND

designThis was a cross-sectional study of children aged <15 years attending six government-run clinics from November 2015 to December 2016. Clinicians completed a standardized patient record form for all child visits. We assessed the following performance indicators of TB evaluation developed based on the Desk Guide of the International Union Against Tuberculosis and Lung Disease, an evidence-based decision aid on childhood TB diagnosis and management for clinicians: proportion screened for TB symptoms or contact history, proportion referred for laboratory evaluation if screen-positive, and proportion treated for TB if test-positive or meeting clinical criteria.

resultsOf 24 566 consecutive children enrolled, 11 614 (47%) were fully screened for TB symptoms. Of 1747 (15%) children who screened positive, 360 (21%) had sputum examined, including 159 (44%) using smear microscopy, 244 (67%) using Xpert® MTB/RIF, and 52 (14%) using both techniques. Treatment was initiated in 18/20 (80%) children who tested positive. An additional 65 screen-positive children met the clinical criteria for TB; none were initiated on treatment.

conclusionsLarge gaps exist along the pathway to diagnosis and treatment of childhood TB. There is an urgent need for enhanced implementation of evidence-based approaches to TB diagnosis to improve outcomes in childhood TB.

Indexed as

AdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornLogistic ModelsMaleMicroscopyMycobacterium tuberculosisPractice Guidelines as TopicPrimary Health CareQuality of Health CareSputum

Identifiers

PMID30236188
PMCPMC6339686

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.