ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018
'Something so hard': a mixed-methods study of home sputum collection for tuberculosis contact investigation in Uganda.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Community views on active case finding for tuberculosis in low- and middle-income countries: a qualitative evidence synthesis.The Cochrane database of systematic reviews · 2024Pooled it
- Tuberculosis disease and infection among household contacts of bacteriologically confirmed vs unconfirmed tuberculosis in Cambodia: considerations for optimising contact investigation and preventive treatment.Annals of medicine · 2026Article
- Sputum scarcity and associated factors in people undergoing tuberculosis testing in South Africa, Uganda, India, and the Philippines: an analysis of cross-sectional observational data.EClinicalMedicine · 2026Article
- Tuberculosis-related stigma and associated factors among people with pulmonary tuberculosis predominantly co-infected with HIV in Kampala, Uganda: a cross-sectional study.Journal of clinical tuberculosis and other mycobacterial diseases · 2026Article
- Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia.BMJ global health · 2025Article
- Case Finding Among and Comprehensive Management of Household Contacts of Persons with Pulmonary Tuberculosis: a Pilot Project - Uganda, 2023-2024.MMWR. Morbidity and mortality weekly report · 2025Article
- A cluster-randomized trial of household vs incentive-based tuberculosis contact investigation in rural South Africa: implementation reach.PLOS global public health · 2025Article
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- Iterative evaluation of mobile computer-assisted digital chest x-ray screening for TB improves efficiency, yield, and outcomes in Nigeria.PLOS global public health · 2024Article
- A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial.BMC public health · 2023Article
- A user-centred implementation strategy for tuberculosis contact investigation in Uganda: Protocol for a stepped-wedge, cluster-randomised trial.Research square · 2023Article
- mHealth to improve implementation of TB contact investigation: a case study from Uganda.Implementation science communications · 2023Article
- The impact of time at home on potential yield of home-based TB contact investigation.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Ending tuberculosis in a post-COVID-19 world: a person-centred, equity-oriented approach.The Lancet. Infectious diseases · 2023Review
- A spatial analysis of TB cases and abnormal X-rays detected through active case-finding in Karachi, Pakistan.Scientific reports · 2023Article
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- Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptionsHIV research & clinical practice · 2022Article
- Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States.Journal of personalized medicine · 2022Article
- Theory-Informed Design of a Tailored Strategy for Implementing Household TB Contact Investigation in Uganda.Frontiers in public health · 2022Article
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9 authors.
Funding
Abstract
backgroundHome sputum collection could facilitate prompt evaluation and diagnosis of tuberculosis (TB) among contacts of patients with active TB. We analyzed barriers to home-based collection as part of an enhanced intervention for household TB contact investigation in Kampala, Uganda.
designWe conducted a convergent mixed-methods study to describe the outcomes of home sputum collection in 91 contacts and examine their context through 19 nested contact interviews and two focus group discussions with lay health workers (LHWs).
resultsLHWs collected sputum from 35 (39%) contacts. Contacts reporting cough were more likely to provide sputum than those with other symptoms or risk factors (53% vs. 15%, RR 3.6, 95%CI 1.5-2.8, P < 0.001). Males were more likely than females to provide sputum (54% vs. 32%, RR 1.7, 95%CI 1.0-2.8, P = 0.05). Contacts said support from the index patient and the convenience of the home visit facilitated collection. Missing containers and difficulty producing sputum spontaneously impeded collection. Women identified stigma as a barrier. LHWs emphasized difficulty in procuring sputum and discomfort pressing contacts to produce sputum.
conclusionsHome sputum collection by LHWs entails different challenges from sputum collection in clinical settings. More research is needed to develop interventions to mitigate stigma and increase success of home-based collection.
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