Observational studyCritical care (London, England)2018
Costs, outcome and cost-effectiveness of neurocritical care: a multi-center observational study.
Observational study in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05593380 (The Impact of Invasive Intracranial Pressure Monitoring Guided Management on the Functional Outcomes of Patients With Supratentorial Large Volume Cerebral Hemorrhage), which is not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Invasive Intracranial Pressure Monitoring Guided Management on the Functional Outcomes of Patients With Supratentorial Large Volume Cerebral Hemorrhage: An Open Label, Randomized, Controlled, Multi-center Trial (BIATICH)
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Systematic Review of Direct Hospital Costs Associated with Aneurysmal Subarachnoid Hemorrhage Management.Neurocritical care · 2026Pooled it
- A Systematic Literature Review on the Burden of Disease for Patients With Moderate to Severe Acute Ischemic Stroke.Medicine · 2025Pooled it
- Imaging predictors of hemorrhagic progression of a contusion after traumatic brain injury: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Ninety-Day Cost, Mortality and Hospital Disparities in Ischemic Stroke: Real-World Evidence from a Czech Administrative Database.Healthcare (Basel, Switzerland) · 2026Article
- Cost-utility framework to evaluate therapeutic interventions targeting reduction in cerebral infarction among aneurysmal subarachnoid hemorrhage patients.Neurosurgical review · 2026Article
- Hospital mortality, withdrawal of life-sustaining therapy decisions and early secondary brain insults for critically ill traumatic brain injury patients in England, Wales and Northern Ireland (2009-2024): an observational cohort study.The Lancet regional health. Europe · 2026Article
- Is it time to develop neurocritical care education in Brazil? Analysis of the Brazilian national survey on education in neurocritical care.Arquivos de neuro-psiquiatria · 2026Article
- Association between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in neurocritical care patients: a retrospective cohort study based on the MIMIC-IV database.European journal of medical research · 2025Article
- Predictors and outcomes associated with prolonged hospital length of stay in intracerebral hemorrhage: a multicenter prospective cohort study in China.BMC medicine · 2025Article
- A case for a bigger role of transcutaneous vagus nerve stimulation in brain injury rehabilitation.Croatian medical journal · 2025Article
- Observational Study of Microbial Colonization and Infection in Neurological Intensive Care Patients Based on Electronic Health Records.Biomedicines · 2025Article
- Novel Post-Neurointensive Care Recovery Clinic: Design, Utilization, and Clinician Perspectives.Neurology. Clinical practice · 2025Article
- Article
- Nationwide epidemiological study of subarachnoid hemorrhage: trends in admissions, mortality, seasonality, costs, clipping, embolization, and the impact of COVID-19.Frontiers in neurology · 2025Article
- The Urban-Rural Divide in Neurocritical Care in Low-Income and Middle-Income Countries.Neurocritical care · 2024Article
- All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion.Neurophotonics · 2024Article
- FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.Cell death & disease · 2024Article
- Variation in Severity-Adjusted Resource use and Outcome for Neurosurgical Emergencies in the Intensive Care Unit.Neurocritical care · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundNeurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treated in the intensive care unit (ICU).
methodsWe used the prospective Finnish Intensive Care Consortium database to identify all adult patients treated for traumatic brain injury (TBI), intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH) and acute ischemic stroke (AIS) at university hospital ICUs in Finland during 2003-2013. Outcome variables were one-year mortality and permanent disability. Total healthcare costs included the index university hospital costs, rehabilitation hospital costs and social security costs up to one year. All costs were converted to euros based on the 2013 currency rate.
resultsIn total 7044 patients were included (44% with TBI, 13% with ICH, 27% with SAH, 16% with AIS). In comparison to TBI, ICH was associated with the highest risk of death and permanent disability (OR 2.6, 95% CI 2.1-3.2 and OR 1.7, 95% CI 1.4-2.1), followed by AIS (OR 1.9, 95% CI 1.5-2.3 and OR 1.5, 95% CI 1.3-1.8) and SAH (OR 1.8, 95% CI 1.5-2.1 and OR 0.8, 95% CI 0.6-0.9), after adjusting for severity of illness. SAH was associated with the highest mean total costs (€51,906) followed by ICH (€47,661), TBI (€43,916) and AIS (€39,222). Cost per independent survivor was lower for TBI (€58,497) and SAH (€96,369) compared to AIS (€104,374) and ICH (€178,071).
conclusionNeurocritical illnesses are costly and resource-demanding diseases associated with poor outcomes. Intensive care of patients with TBI or SAH more commonly result in independent survivors and is associated with lower total treatments costs compared to ICH and AIS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.