Evidence map›Paper›PMID 30236131›Full record

ArticleRetrovirology2018

Potent suppression of HIV-1 cell attachment by Kudzu root extract.

S Mediouni, J A Jablonski, S Tsuda, A Richard, C Kessing, M V Andrade, A Biswas, Y Even, T Tellinghuisen, H Choe and 3 more

Open access · goldAbstract read
In one paragraph

Article in Retrovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  5. Effect ofFrontiers in pharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

S MediouniDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
J A JablonskiDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
S TsudaDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
A RichardDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
C KessingDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
M V AndradeUniversity of Miami Miller School of Medicine, Miami, FL, USA.
A BiswasDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
Y EvenThe Botanist's Beach Farm, Jupiter, FL, USA.
T TellinghuisenDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
H ChoeDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA.
M CameronDepartment of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, USA.
M StevensonUniversity of Miami Miller School of Medicine, Miami, FL, USA.
S T ValenteDepartment of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL, 33458, USA. svalente@scripps.edu.
Scripps Research Institute · USUniversity of Miami · USRoche (Switzerland) · CH

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
NIAID NIH HHS P30 AI073961
6 · The paper itself

Abstract

There is a constant need to improve antiretrovirals against HIV since therapy is limited by cost, side effects and the emergence of drug resistance. Kudzu is a climbing vine from which the root extract (Pueraria lobata), rich in isoflavones and saponins, has long been used in traditional Chinese medicine for a variety of purposes, from weight loss to alcoholism prevention. Here we show that Kudzu root extract significantly inhibits HIV-1 entry into cell lines, primary human CD4

Indexed as

PuerariaAnimalsAnti-HIV AgentsCells, CulturedDrug SynergismEnfuvirtideHIV-1HIV Envelope Protein gp120HumansPlant ExtractsPlant RootsVirus AttachmentVirus ReplicationAnti-HIV AgentsEnfuvirtideHIV Envelope Protein gp120Plant Extracts

Identifiers

PMID30236131
PMCPMC6149077
OpenAlexW2890393963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.