ArticleVirology journal2018
Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples.
Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Anelloviruses: From General Biology to Their Role as Biomarkers of Immune Competence in HIV Infection.Viruses · 2026Review
- Interactions between extracellular vesicles and viruses: lessons learned across species and kingdoms.FEMS microbiology reviews · 2026Review
- Identification and characterization of a novel plaque-invisible lytic single-stranded RNA phage.Journal of virology · 2025Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
- Review
- Transfusion-Transmitted Disorders 2023 with Special Attention to Bone Marrow Transplant Patients.Pathogens (Basel, Switzerland) · 2023Review
- Editorial: Torquetenovirus: predictive biomarker or innocent bystander in pathogenesis.Frontiers in medicine · 2023Article
- TTV and other anelloviruses: The astonishingly wide spread of a viral infection.Aspects of molecular medicine · 2023Review
- Plasma-derived exosomal miRNA as potential biomarker for diagnosis and prognosis of vector-borne diseases: A review.Frontiers in microbiology · 2023Review
- Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases.Microorganisms · 2021Review
- Torque teno virus in liver diseases and after liver transplantation.World journal of transplantation · 2020Article
- Human anelloviruses: diverse, omnipresent and commensal members of the virome.FEMS microbiology reviews · 2020Review
- microRNA and exosome profiling in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Review
- Molecular Epidemiology of Anellovirus Infection in Children's Urine: A Cross-sectional Study.Advanced biomedical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTorquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence in the host. Here, the presence of TTV in extracellular vesicles circulating in human plasma was investigated.
methodsTTV DNA was quantified in plasma-derived exosomes from 122 samples collected from 97 diseased patients and 25 healthy donors. Exosomes enriched vesicles (EEVs) were extracted from plasma and characterized by Nanoparticle tracking analysis, by western blot for presence of tetraspanin CD63, CD81 and annexin II protein and, finally, by electron microscopy (EM). Presence and quantitation of TTV DNA were assessed with an universal single step real-time TaqMan PCR assay.
resultsPreliminary investigation showed that the human plasma extracted extracellular vesicles exhibited a main size of 70 nm, had concentration of 2.5 × 10
conclusionsCollectively, although these observations should be confirmed by further studies, circulation of TTV particles in EEVs opens new avenues and mechanistic insights on the molecular strategies adopted by anelloviruses to persist in the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.