ArticleCritical care (London, England)2018
Regional expiratory time constants in severe respiratory failure estimated by electrical impedance tomography: a feasibility study.
Article in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06236685 (Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features.Nature communications · 2025Trial
- Global mechanical power does not determine regional energy distribution in heterogeneous lungs.Frontiers in physiology · 2026Article
- EIT-guided chest physiotherapy for airway clearance during awake prone ventilation in ARDS: a randomized controlled trial.Journal of thoracic disease · 2025Article
- Recommendations for lung ventilation and perfusion assessment with chest electrical impedance tomography in critically ill adult patients: an international evidence-based and expert Delphi consensus study.EClinicalMedicine · 2025Article
- Simultaneous Acquisition of EIT and ECG Signals on Active EIT Electrodes.IEEE transactions on bio-medical engineering · 2025Article
- Expiratory time constants in mechanically ventilated patients: rethinking the old concept-a narrative review.Intensive care medicine experimental · 2025Review
- Bioimpedance measurements of fibrotic and acutely injured lung tissues.Acta biomaterialia · 2025Article
- Electrical impedance tomography reveals regional lung dysfunction in adults with preserved ratio impaired spirometry: an observational cross-sectional study.Frontiers in medicine · 2025Article
- Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study.Intensive care medicine experimental · 2024Article
- Electrical impedance tomography as a bedside assessment tool for COPD treatment during hospitalization.Frontiers in physiology · 2024Article
- Effect of routine suction on lung aeration in critically ill neonates and young infants measured with electrical impedance tomography.Scientific reports · 2023Observational
- Clinical Applicability of Electrical Impedance Tomography in Patient-Tailored Ventilation: A Narrative Review.Tomography (Ann Arbor, Mich.) · 2023Review
- Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19-Insights from PRoVENT-COVID.Journal of clinical medicine · 2023Article
- Evaluation of lung function in a German single center cohort of young patients with sickle cell disease using EIT and standard techniques.Frontiers in medicine · 2023Article
- Structural priors represented by discrete cosine transform improve EIT functional imaging.PloS one · 2023Article
- Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease.Critical care (London, England) · 2022Article
- Improved resolution of D-bar images of ventilation using a Schur complement property and an anatomical atlas.Medical physics · 2022Article
- Expert opinion document: "Electrical impedance tomography: applications from the intensive care unit and beyond".Journal of anesthesia, analgesia and critical care · 2022Review
- Lung aeration, ventilation, and perfusion imaging.Current opinion in critical care · 2022Review
- Thoracic Electrical Impedance Tomography-The 2022 Veterinary Consensus Statement.Frontiers in veterinary science · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrical impedance tomography (EIT) has been used to guide mechanical ventilation in ICU patients with lung collapse. Its use in patients with obstructive pulmonary diseases has been rare since obstructions could not be monitored on a regional level at the bedside. The current study therefore determines breath-by-breath regional expiratory time constants in intubated patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS).
methodsExpiratory time constants calculated from the global impedance EIT signal were compared to the pneumatic volume signals measured with an electronic pneumotachograph. EIT-derived expiratory time constants were additionally determined on a regional and pixelwise level. However, regional EIT signals on a single pixel level could in principle not be compared with similar pneumatic changes since these measurements cannot be obtained in patients. For this study, EIT measurements were conducted in 14 intubated patients (mean Simplified Acute Physiology Score II (SAPS II) 35 ± 10, mean time on invasive mechanical ventilation 36 ± 26 days) under four different positive end-expiratory pressure (PEEP) levels ranging from 10 to 17 cmH
resultsSpearman's correlation coefficient for comparison between EIT-derived time constants and those from flow/volume curves was between 0.78 for tau (τ) calculated from the global impedance signal up to 0.83 for the mean of all pixelwise calculated regional impedance changes over the entire PEEP range. Furthermore, Bland-Altman analysis revealed a corresponding bias of 0.02 and 0.14 s within the limits of agreement ranging from - 0.50 to 0.65 s for the aforementioned calculation methods. In addition, exemplarily in patients with moderate-severe ARDS or COPD exacerbation, different PEEP levels were shown to have an influence on the distribution pattern of regional time constants.
conclusionsEIT-based determination of breath-by-breath regional expiratory time constants is technically feasible, reliable and valid in invasively ventilated patients with severe respiratory failure and provides a promising tool to individually adjust mechanical ventilation in response to the patterns of regional airflow obstruction.
trial registrationGerman Trial Register DRKS 00011650 , registered 01/31/17.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.