ArticleBiomedical engineering online2018
Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Integrated Diagnosis and Therapy Using Flexible Contact Electrodes: Low-Voltage Irreversible Electroporation and Quantitative Assessment of Therapeutic Efficacy.Annals of biomedical engineering · 2026Article
- Compound steep-pulse irreversible electroporation for prostate ablation in Beagle dogs: parameter evaluation and short-term safety.Frontiers in urology · 2026Article
- Distribution of relaxation times as a tool to monitor tissue electroporation.Scientific reports · 2025Article
- Bioimpedance assessment method based on back propagation neural network for irreversible electroporation of liver tissue.Scientific reports · 2025Article
- Non-contact electroacoustic tomography with optical interferometer for electroporation therapy monitoring.Applied physics letters · 2025Article
- Real-time monitoring of bioelectrical impedance for minimizing tissue carbonization in microwave ablation of porcine liver.Scientific reports · 2024Article
- In Vitro Assay Development to Study Pulse Field Ablation Outcome Using Solanum Tuberosum.International journal of molecular sciences · 2024Article
- Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction.Circulation research · 2023Article
- Electrochemical Testing of a New Polyimide Thin Film Electrode for Stimulation, Recording, and Monitoring of Brain Activity.Micromachines · 2022Article
- Determining tissue conductivity in tissue ablation by nanosecond pulsed electric fields.Bioelectrochemistry (Amsterdam, Netherlands) · 2022Article
- Evaluation of electroporated area using 2,3,5-triphenyltetrazolium chloride in a potato model.Scientific reports · 2021Article
- Rapid Impedance Spectroscopy for Monitoring Tissue Impedance, Temperature, and Treatment Outcome During Electroporation-Based Therapies.IEEE transactions on bio-medical engineering · 2021Article
- Design and Characterization of a Minimally Invasive Bipolar Electrode for Electroporation.Biology · 2020Article
- Real-Time Impedance Monitoring During Electroporation Processes in Vegetal Tissue Using a High-Performance Generator.Sensors (Basel, Switzerland) · 2020Article
- Development of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fields.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIrreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions.
methodsUsing a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results.
resultsThe change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers.
conclusionsThe relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.