ArticleBMC cancer2018
A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
220 citing papers in PubMed, 2 syntheses or guidelines pooled it, 417 citations in OpenAlex.
- Colorectal cancer treatment in people with severe mental illness: a systematic review and meta-analysis.Epidemiology and psychiatric sciences · 2022Pooled it
- A systematic review of microbial markers for risk prediction of colorectal neoplasia.British journal of cancer · 2022Pooled it
- Effectiveness of Colonoscopy Screening vs Sigmoidoscopy Screening in Colorectal Cancer.JAMA network open · 2024Trial
- Trial
- Forecasting colorectal cancer screening in Japan: regional and sex disparities threaten national targets.International journal of clinical oncology · 2026Article
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- Influence of MASLD and MAFLD on long-term extrahepatic cancer incidence and cancer mortality in regional Australia.Internal medicine journal · 2026Article
- Colorectal cancer incidence and survival trends in Uganda: a population-based registry analysis (2000-20).International journal of epidemiology · 2026Article
- Gender-based differences in colorectal cancer screening uptake in Singapore: a cross-sectional study.Family practice · 2026Article
- Sex Differences in Colorectal Tumor-Associated T-cell Responses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Epidemiology of colonic adenoma and cancer.Clinical endoscopy · 2026Review
- Sex ratio disparities in the two most common cancers worldwide: an exploratory analysis using GLOBOCAN 2022 data, gender inequalities, and economic indicators.EClinicalMedicine · 2026Article
- Nationwide analysis on sex differences in diagnosis, treatment and survival of rectal cancer.Biology of sex differences · 2026Article
- Intersectional inequalities in advanced stage diagnosis of colorectal cancer in England: a cross-sectional study of National Cancer Registry data from 2013 to 2019.Journal of epidemiology and community health · 2026Article
- Sociodemographic variation in symptomatic faecal immunochemical testing return: a population-based analysis of 125 659 patients.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Prospective validation of the modified metastatic colorectal cancer score (mCCS) in >600 patients with RAS-wild-type metastatic colorectal cancer treated with first-line panitumumab plus FOLFIRI/FOLFOX: Final results of the non-interventional study VALIDATE.International journal of cancer · 2026Article
- Article
- Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut.Frontiers in endocrinology · 2026Review
- Analysis of Risk Factors and Assessment of miRNA-122 as a Novel Biomarker for Colon Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation.NPJ digital medicine · 2025Article
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer (CRC) is an illness strongly influenced by sex and gender, with mortality rates in males significantly higher than females. There is still a dearth of understanding on where sex differences exist along the pathway from presentation to survival. The aim of this review is to identify where actions are needed to improve outcomes for both sexes, and to narrow the gap for CRC.
methodsA cross-sectional review of national data was undertaken to identify sex differences in incidence, screening uptake, route to diagnosis, cancer stage at diagnosis and survival, and their influence in the sex differences in mortality.
resultsOverall incidence is higher in men, with an earlier age distribution, however, important sex differences exist in anatomical site. There were relatively small differences in screening uptake, route to diagnosis, cancer staging at diagnosis and survival. Screening uptake is higher in women under 69 years. Women are more likely to present as emergency cases, with more men diagnosed through screening and two-week-wait. No sex differences are seen in diagnosis for more advanced disease. Overall, age-standardised 5-year survival is similar between the sexes.
conclusionsAs there are minimal sex differences in the data from routes to diagnosis to survival, the higher mortality of colorectal cancer in men appears to be a result of exogenous and/or endogenous factors pre-diagnosis that lead to higher incidence rates. There are however, sex and gender differences that suggest more targeted interventions may facilitate prevention and earlier diagnosis in both men and women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.