ArticleNutrients2018
Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Nonalcoholic Beverage Consumption and the Risk of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis.Depression and anxiety · 2026Pooled it
- Association between dietary caffeine, coffee, and tea consumption and depressive symptoms in adults: A systematic review and dose-response meta-analysis of observational studies.Frontiers in nutrition · 2023Pooled it
- Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Tea and coffee consumption in relation to depression and anxiety symptoms: findings from the multicentric LIPOKAP study.Scientific reports · 2026Article
- The effects of coffee and caffeine consumption on plasma and salivary biomarkers associated with mood in a healthy population.Metabolic brain disease · 2025Article
- Omega-3 Fatty Acid Fortification of Plant-Based Beverages to Enhance Their Nutritional Profile.Foods (Basel, Switzerland) · 2025Review
- Longitudinal Effects of Lifetime Caffeine Consumption on Levels of Depression, Anxiety, and Stress: A Comprehensive Review.Current nutrition reports · 2025Review
- Association of caffeine intake and sleep duration with bone mineral density: a cross-sectional study from National Health and Nutrition Examination Survey between 2011 and 2018.BMC musculoskeletal disorders · 2025Article
- The caffeine dilemma: unraveling the intricate relationship between caffeine use disorder, caffeine withdrawal symptoms and mental well-being in adults.Public health nutrition · 2024Article
- Prevalence of anhedonia, anxiety, and their impact on food consumption among postgraduate Qassim University students.Frontiers in nutrition · 2024Article
- Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.Nature communications · 2023Article
- Striatopallidal adenosine ANeuropharmacology · 2023Review
- Coffee and caffeine intake and depression in postpartum women: A cross-sectional study from the National Health and Nutrition Examination Survey 2007-2018.Frontiers in psychology · 2023Article
- Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?Frontiers in nutrition · 2023Article
- Sex and age disparities in the influence of tobacco smoking on depression: Evidence from the Taiwan Biobank.Tobacco induced diseases · 2023Article
- The relationships between use of alcohol, tobacco and coffee in adolescence and mood disorders in adulthood.Acta psychiatrica Scandinavica · 2022Article
- Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- Can coffee silverskin be a useful tool to fight metabolic syndrome?Frontiers in nutrition · 2022Review
- The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We assessed the relationship between coffee intake and the risk of depression, controlling for adherence to the Mediterranean diet. We studied 14,413 university graduates of the 'Seguimiento Universidad de Navarra' (SUN) cohort, initially free of depression. We evaluated coffee consumption using a validated food-frequency questionnaire (FFQ). Incident depression cases were adjudicated only if the participant met two criteria simultaneously: (a) validated physician-diagnosed depression together with (b) new onset of habitual antidepressant use. Both criteria were needed; participants meeting only one of them were not classified as cases. Participants who drank at least four cups of coffee per day showed a significantly lower risk of depression than participants who drank less than one cup of coffee per day (HR: 0.37 (95% CI 0.15⁻0.95)). However, overall, we did not observe an inverse linear dose⁻response association between coffee consumption and the incidence of depression (
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