ArticleInternational journal of molecular sciences2018
Guanidinoacetic Acid Regulates Myogenic Differentiation and Muscle Growth Through miR-133a-3p and miR-1a-3p Co-mediated Akt/mTOR/S6K Signaling Pathway.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 123 citations in OpenAlex.
- Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Enhancement of growth performance, muscle nutrient composition, and nutritional value in rainbow trout (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effect of Amino Acid Derivatives and Polyphenol Supplementation on Ovine Muscle Growth In Vitro and In Vivo.Muscles (Basel, Switzerland) · 2026Article
- Blood metabolic panels for identifying significant fibrosis and inflammation in patients with MASLD.Cell reports. Medicine · 2026Article
- Intricacies of PKB/Akt Activity after Sciatic Nerve Damage: A Comprehensive Review.Current protein & peptide science · 2026Review
- MiR-1a-3p/Fcgr4-dependent osteoclast activation regulates pathological bone loss.Frontiers in immunology · 2026Article
- Effect of Guanidinoacetic Acid and Zilpaterol Hydrochloride Feed Additions on Lambs' Productive Performance, Carcass Characteristics, and Blood Chemistry.Animals : an open access journal from MDPI · 2025Article
- Article
- Guanidinoacetic Acid and Methionine Supplementation Improve the Growth Performance of Beef Cattle via Regulating the Antioxidant Levels and Protein and Lipid Metabolisms in Serum and Liver.Antioxidants (Basel, Switzerland) · 2025Article
- Performance Responses and Fillet Quality of Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
- Rumen-protected guanidinoacetic acid improves growth performance in beef cattle under chronic heat stress by reshaping gut microbiota and modulating serum metabolism.Frontiers in microbiology · 2025Article
- Profiling of blood miRNAomes revealed the potential regulatory role of miRNAs in various lameness phenotypes in feedlot cattle.BMC genomics · 2024Article
- Guanidinoacetic acid supplementation and stocking density effects on broiler performance: behavior, biochemistry, immunity, and small intestinal histomorphology.Acta veterinaria Scandinavica · 2024Article
- Effects of Guanidine Acetic Acid on the Growth and Slaughter Performance, Meat Quality, Antioxidant Capacity, and Cecal Microbiota of Broiler Chickens.Veterinary sciences · 2024Article
- Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies.Journal of animal science and biotechnology · 2024Article
- Transcriptome analysis of mRNA and miRNA in the development of LeiZhou goat muscles.Scientific reports · 2024Article
- Analysis of microRNA Expression Profiles in Broiler Muscle Tissues by Feeding Different Levels of Guanidinoacetic Acid.Current issues in molecular biology · 2024Article
- Evaluation of guanidinoacetic acid supplementation on finishing beef steer growth performance, skeletal muscle cellular response, and carcass characteristics.Journal of animal science · 2024Article
- Construction of LncRNA-Related ceRNA Networks in Longissimus Dorsi Muscle of Jinfen White Pigs at Different Developmental Stages.Current issues in molecular biology · 2024Article
- Association analysis of transcriptome and quasi-targeted metabolomics reveals the regulation mechanism underlying broiler muscle tissue development at different levels of dietary guanidinoacetic acid.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Guanidinoacetic acid (GAA), an amino acid derivative that is endogenous to animal tissues including muscle and nerve, has been reported to enhance muscular performance. MicroRNA (miRNA) is a post-transcriptional regulator that plays a key role in nutrient-mediated myogenesis. However, the effects of GAA on myogenic differentiation and skeletal muscle growth, and the potential regulatory mechanisms of miRNA in these processes have not been elucidated. In this study, we investigated the effects of GAA on proliferation, differentiation, and growth in C2C12 cells and mice. The results showed that GAA markedly inhibited the proliferation of myoblasts, along with the down-regulation of cyclin D1 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.