Evidence map›Paper›PMID 30235871›Full record

ArticleInternational journal of molecular sciences2018

Deep Brain Stimulation Modified Autism-Like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model.

Han-Fang Wu, Yi-Ju Chen, Ming-Chia Chu, Ya-Ting Hsu, Ting-Yi Lu, I-Tuan Chen, Po See Chen, Hui-Ching Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  7. Generational synaptic functions of GABAJournal of biomedical science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Han-Fang WuDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. sindy7941@gmail.com.
Yi-Ju ChenDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. m0935540692@gmail.com.
Ming-Chia ChuDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. sanwy47507@gmail.com.
Ya-Ting HsuDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. happylullaby@hotmail.com.
Ting-Yi LuDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. b0133021@gmail.com.
I-Tuan ChenDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. tim8315@gmail.com.
Po See ChenDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. chenps@mail.ncku.edu.tw.ORCID 0000-0003-4963-578X
Hui-Ching LinDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. hclin7@ym.edu.tw.ORCID 0000-0002-1639-9293
National Yang Ming Chiao Tung University · TWNational Cheng Kung University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2628-B-010-006-MY3, MOST 103-2320-B-010-014-MY2, MOST 103-2321-B-010-006National Yang-Ming University-Far Eastern Memorial Hospital Joint Research Program #NYMU-FEMH 106DN09Yen Tjing Ling Medical Foundation CI-105-12
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is known to be a promising treatment for resistant depression, which acts via the serotonin (5-hydroxytryptamine, 5-HT) system in the infralimbic prefrontal cortex (ILPFC). Previous study revealed that dysfunction of brain 5-HT homeostasis is related to a valproate (VPA)-induced rat autism spectrum disorder (ASD) model. Whether ILPFC DBS rescues deficits in VPA-induced offspring through the 5-HT system is not known. Using VPA-induced offspring, we therefore explored the effect of DBS in autistic phenotypes and further investigated the underlying mechanism. Using combined behavioral and molecular approaches, we observed that applying DBS and 5-HT

Indexed as

Deep Brain Stimulation8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsAutism Spectrum DisorderMalePrefrontal CortexRatsRats, Sprague-DawleyReceptors, GABA-AReceptors, N-Methyl-D-AspartateSerotoninSerotonin 5-HT1 Receptor AgonistsValproic Acid8-Hydroxy-2-(di-n-propylamino)tetralinReceptors, GABA-AReceptors, N-Methyl-D-AspartateSerotoninSerotonin 5-HT1 Receptor AgonistsValproic Acidautism spectrum disorderdeep brain stimulationserotonin systemvalproic acid

Identifiers

PMID30235871
PMCPMC6164279
OpenAlexW2890169762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.