Evidence map›Paper›PMID 30235847›Full record

ReviewCancers2018

Autologous Transplantation for Older Adults with AML.

Beatrice U Mueller, Katja Seipel, Ulrike Bacher, Thomas Pabst

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Prostaglandin EStem cell reviews and reports · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Beatrice U MuellerDepartment of BioMedical Research, University of Bern, 3010 Berne, Switzerland. beatrice.mueller@insel.ch.
Katja SeipelDepartment of BioMedical Research, University of Bern, 3010 Berne, Switzerland. katja.seipel@dbmr.unibe.ch.
Ulrike BacherDepartment of Hematology, University of Bern, 3010 Berne, Switzerland. veraulrike.bacher@insel.ch.
Thomas PabstDepartment of Medical Oncology, Inselspital, Bern University Hospital, 3010 Berne, Switzerland. thomas.pabst@insel.ch.
University of Bern · CHUniversity Hospital of Bern · CH

Funding

EMPIRIS Foundation/Ursula-Hecht Fonds 01A-2018
6 · The paper itself

Abstract

While the majority of patients with acute myeloid leukemia (AML) are above the age of 65 years at diagnosis, the outcome of older AML patients remains disappointing. Even if standard intensive chemotherapy induces morphologic complete remission (CR1), relapses in older AML patients are common leading to poor long-term survival outcomes. Since autologous hematopoietic stem cell transplantation (HCT) offers distinct anti-leukemic effectiveness while avoiding graft-versus-host disease associated with allogeneic transplantation, it represents an option for consolidation treatment in selected older AML patients. However, prospective studies in older AML patients assessing the benefit of autologous HCT compared to chemotherapy consolidation or allogeneic transplantation are lacking. Consequently, clinicians face the dilemma that there is considerable ambiguity on the most appropriate consolidation treatment for older AML patients in CR1. This review highlights the possible role of autologous HCT for consolidation in older AML patients reaching CR1 after induction treatment.

Indexed as

AMLautologouselderlyolderoutcomereviewsurvivaltransplantation

Identifiers

PMID30235847
PMCPMC6162649
OpenAlexW2891363421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.