Evidence map›Paper›PMID 30235663›Full record

Observational studyMedicine2018

Clinical features and outcomes of gastric neuroendocrine tumors after endoscopic diagnosis and treatment: A Digestive Endoscopy Society of Tawian (DEST).

Chen-Shuan Chung, Cho-Lun Tsai, Yin-Yi Chu, Kuan-Chih Chen, Jung-Chun Lin, Bao-Chung Chen, Wei-Chih Sun, Hsu-Heng Yen, Chiung-Yu Chen, I-Chen Wu and 12 more

Erratum issuedOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Guideline
  2. Type 2 and type 3 gastric neuroendocrine tumors have high risk of lymph node metastasis: Systematic review and meta-analysis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. EUS-guided glue injection for managing torrential bleeding during gastric neuroendocrine tumor endoscopic submucosal dissection: sealing the storm.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Gastric neuroendocrine neoplasms.Nature reviews. Disease primers · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Clinical characteristics and long-term prognosis of type 1 gastric neuroendocrine tumors in a large Japanese national cohort.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 19 institutions in 1 country.

Chen-Shuan ChungDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, Banciao District College of Medicine, Fu Jen Catholic University, New Taipei City Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veteran General Hospital, Kaohsiung Endoscopy Center, Changhua Christian Hospital, Changhua City Division of Gastroenterology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital Division of Gastroenterology, Department of Internal Medicine, Taipei City Hospital, Renai Branch, Taipei Department of Internal Medicine, National Taiwan University Hospital, Hsinchu branch, Hsinchu Gastroenterology, En Chu Kong Hospital, New Taipei City Department of Internal Medicine, Min-Sheng General Hospital, Taoyuan Department of Laboratoty Medicine, National Taiwan University Hospital, Taipei Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University, Kaohsiung Division of Gastroenterology, Chung Shan Medical University Hospital, Taichung Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Cho-Lun Tsai
Yin-Yi Chu
Kuan-Chih Chen
Jung-Chun Lin
Bao-Chung Chen
Wei-Chih Sun
Hsu-Heng Yen
Chiung-Yu Chen
I-Chen Wu
Chao-Hung Kuo
Hisang-Yao Shih
Ming-Jong Bair
Jack P Wang
Wen-Hao Hu
Chang-Shyue Yang
Ming-Lun Han
Tsu-Yao Cheng
Chao-Ming Tseng
Ming-Chang Tsai
Ming-Luen Hu
Hsiu-Po Wang
National Taiwan University Hospital · TWKaohsiung Medical University · TWChang Gung Memorial Hospital · TWChang Gung University · TWChanghua Christian Hospital · TWChia-Yi Christian Hospital · TWChung Shan Medical University Hospital · TWEn Chu Kong Hospital · TWFar Eastern Memorial Hospital · TWI-Shou University · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWKaohsiung Veterans General Hospital · TWMackay Memorial Hospital · TWMin Sheng General Hospital · TWNational Cheng Kung University Hospital · TWNational Defense Medical Center · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric neuroendocrine tumors (GNETs) are a heterogeneous group of neoplasm with varying biological characteristics. This study aimed to investigate the clinical features and outcomes of GNET patients after endoscopic diagnosis and treatment in a multicenter registry. Patients with GNETs confirmed histologically were recruited from 17 hospitals between January 2010 and April 2016 in Taiwan. Clinical, laboratory, radiological, endoscopic, pathological data, treatment strategies, follow-up periods, and survivals were collected retrospectively. Totally 187 (107 female, 80 male) patients were recruited. Mean ( ± standard deviation [SD]) age and size of tumors were 63.2-year-old ( ± 14.6) and 2.3-cm ( ± 3.0). World Health Organization (WHO) grading were 93 (49.7%) G1, 26 (13.9%) G2, 40 (21.4%) G3, and 28 (15.0%) unknown. G3 patients were older (mean ± SD, 71.6 ± 12.4 vs. 60.9 ± 14.3/56.7 ± 15.4 years), larger (6.1 ± 4.0 vs.1.2 ± 1.3/2.4 ± 2.5 cm), more distally located (35.0% vs. 7.6%/15.4%), lower proportion of superficial lesions (17.5% vs. 61.9%/53.8%) and higher rates of lymphovascular invasion (32.5% vs. 3.2%/7.7%) than G1/G2. There was no nodal or distant organ metastases despite different grading of lesions≦10 mm and those <20 mm limited to mucosa and submucosa layers. GNETs larger than 20 mm with G1, G2, and G3 had lymph node (LN) metastatic rates of 21.4%, 30.0%, and 59.3%, respectively. Survivals were different between grading for those >20 mm (log-rank test P = .02). Male gender (P = .01), deeper invasion (P = .0001), nodal (P < .0001), and distant organ metastases (P = .0001) were associated with worse outcome. In conclusion, treatment strategies for GNET should be decided by grading, size, invasiveness, and LN metastasis risk. Curative endoscopic resection is feasible for G1/2 lesions less than 20 mm and limited to mucosa/submucosa layers without lymphovascular invasion.

Indexed as

AdultAgedAged, 80 and overAge DistributionBiomarkers, TumorEndoscopy, GastrointestinalFemaleGastric MucosaHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeuroendocrine TumorsBiomarkers, Tumor

Identifiers

PMID30235663
PMCPMC6160255
OpenAlexW2912161963

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.