SynthesisMedicine2018
The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis.The Journal of international medical research · 2020Pooled it
- Analgesic effect of pulsed electromagnetic fields for mammaplasty: A meta-analysis of randomized controlled studies.Medicine · 2020Pooled it
- The efficacy of perioperative gabapentin for the treatment of postoperative pain following total knee and hip arthroplasty: a meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- PROSPECT guideline for oncological breast surgery: a systematic review and procedure-specific postoperative pain management recommendations.Anaesthesia · 2020Guideline
- Randomized, double-blind trial of preoperative pregabalin versus placebo to improve quality of recovery after breast cancer surgery.Brazilian journal of anesthesiology (Elsevier)Trial
- Regional and Temporal Variation in Receipt of Gabapentinoid and SSRI/SNRI Therapy Among Older Cancer Survivors in the United States.Current oncology (Toronto, Ont.) · 2025Article
- Electronic health record interventions to reduce postoperative pregabalin prescribing: a quality improvement initiative.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Observational
- Rebound Pain After Regional Anaesthesia.Medicina (Kaunas, Lithuania) · 2025Review
- Nerve Block on Pain After Mammaplasty: A Meta-Analysis of randomized controlled studies.Plastic surgery (Oakville, Ont.) · 2022Review
- Effect of Sufentanil Combined with Gabapentin on Acute Postoperative Pain in Patients Undergoing Intraspinal Tumor Resection: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2022Article
- Gabapentin enhances the antinociceptive effect of intrathecal morphine in refractory cancer pain patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Dual-trajectories of opioid and gabapentinoid use and risk of subsequent drug overdose among Medicare beneficiaries in the United States: a retrospective cohort study.Addiction (Abingdon, England) · 2021Article
- The combined analgesic effect of pregabalin and morphine in the treatment of pancreatic cancer pain, a retrospective study.Cancer medicine · 2021Article
- Optimizing Perioperative Use of Opioids: A Multimodal Approach.Current anesthesiology reports · 2020Article
- Application of positive behavior management in patients after breast cancer surgery.World journal of clinical cases · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery.
methodsIn November 2017, a systematic computer-based search was conducted in PubMed, Embase, Web of Science, Cochrane Library, and Google databases. RCTs comparing gabapentin with placebo in patients undergoing breast cancer surgery were retrieved. The primary endpoint was the visual analog scale (VAS) after surgery and 24 hours after surgery and total morphine consumption. The secondary outcomes were incidence of chronic pain and complications (the incidence of nausea). Software Stata 12.0 was used for meta-analysis.
resultsFinally, 9 RCTs were included in the meta-analysis. Results indicated that gabapentin was associated with reduced pain scores after surgery and 24 hours after surgery. Meanwhile, oral gabapentin was associated with a reduction of the total morphine consumption after breast cancer surgery. Similarly, gabapentin was associated with a reduction in the incidence of chronic pain and the incidence of nausea.
conclusionsPreoperative use of gabapentin was able to reduce acute and chronic postoperative pain, total morphine consumption and the occurrence of nausea following breast cancer surgery. Further studies should determine the optimal dose of gabapentin for pain control after breast cancer surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.