ArticlePloS one2018
Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Palatal segment contributions to midfacial anterior-posterior growth.Journal of anatomy · 2025Article
- Palatal segment contributions to midfacial anterior-posterior growth.bioRxiv : the preprint server for biology · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.Frontiers in cell and developmental biology · 2023Article
- Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans.Scientific reports · 2021Article
- Distal extension of palatal rugae as a limitation for donor soft tissue grafts in a Jordanian population: A cross-sectional study.BMC oral health · 2021Article
- LRPs in WNT Signalling.Handbook of experimental pharmacology · 2021Review
- Palatal rugae morphology is associated with variation in tooth number.Scientific reports · 2020Observational
- Genetics and signaling mechanisms of orofacial clefts.Birth defects research · 2020Review
- Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.Disease models & mechanisms · 2019Review
- Sonic hedgehog signaling in craniofacial development.Differentiation; research in biological diversityReview
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Authors and funding
16 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Periodic patterning of iterative structures is diverse across the animal kingdom. Clarifying the molecular mechanisms involved in the formation of these structure helps to elucidate the process of organogenesis. Turing-type reaction-diffusion mechanisms have been shown to play a critical role in regulating periodic patterning in organogenesis. Palatal rugae are periodically patterned ridges situated on the hard palate of mammals. We have previously shown that the palatal rugae develop by a Turing-type reaction-diffusion mechanism, which is reliant upon Shh (as an inhibitor) and Fgf (as an activator) signaling for appropriate organization of these structures. The disturbance of Shh and Fgf signaling lead to disorganized palatal rugae. However, the mechanism itself is not fully understood. Here we found that Lrp4 (transmembrane protein) was expressed in a complementary pattern to Wise (a secreted BMP antagonist and Wnt modulator) expression in palatal rugae development, representing Lrp4 expression in developing rugae and Wise in the inter-rugal epithelium. Highly disorganized palatal rugae was observed in both Wise and Lrp4 mutant mice, and these mutants also showed the downregulation of Shh signaling, which was accompanied with upregulation of Fgf signaling. Wise and Lrp4 are thus likely to control palatal rugae development by regulating reaction-diffusion mechanisms through Shh and Fgf signaling. We also found that Bmp and Wnt signaling were partially involved in this mechanism.
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