Evidence map›Paper›PMID 30234973›Full record

ArticleACS nano2018

Bioengineered Norovirus S

Ming Xia, Pengwei Huang, Chen Sun, Ling Han, Frank S Vago, Kunpeng Li, Weiming Zhong, Wen Jiang, John S Klassen, Xi Jiang and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  6. EngineeringVaccines · 2024
    Review
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  14. The αTSR Domain ofInternational journal of nanomedicine · 2023
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ming XiaDivision of Infectious Diseases , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio 45229 , United States.
Pengwei HuangDivision of Infectious Diseases , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio 45229 , United States.
Chen SunDepartment of Biological Sciences, Purdue Cryo-EM Facility , Purdue University , West Lafayette , Indiana 47907 , United States.
Ling HanDepartment of Chemistry , University of Alberta , Alberta T6G 2G2 , Canada.
Frank S VagoDepartment of Biological Sciences, Purdue Cryo-EM Facility , Purdue University , West Lafayette , Indiana 47907 , United States.
Kunpeng LiDepartment of Biological Sciences, Purdue Cryo-EM Facility , Purdue University , West Lafayette , Indiana 47907 , United States.
Weiming ZhongDivision of Infectious Diseases , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio 45229 , United States.
Wen JiangDepartment of Biological Sciences, Purdue Cryo-EM Facility , Purdue University , West Lafayette , Indiana 47907 , United States.
John S KlassenDepartment of Chemistry , University of Alberta , Alberta T6G 2G2 , Canada.ORCID 0000-0002-3389-7112
Xi JiangDivision of Infectious Diseases , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio 45229 , United States.
Ming TanDivision of Infectious Diseases , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio 45229 , United States.ORCID 0000-0002-6489-5507
Cincinnati Children's Hospital Medical Center · USPurdue University West Lafayette · USUniversity of Alberta · CA

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Novel vaccine against NorovirusR01AI089634 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, XI · 2010 to 2014
$4.7M
A novel lactic acid bacteria-based norovirus vaccineR01AI123661 · NIAID · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N, HE, XIAOMING · 2016 to 2020
$3.0M
HBGA receptors in host cell entry and infection of norovirusR01AI111095 · NIAID · PURDUE UNIVERSITY · PI JIANG, WEN, JIANG, XI · 2015 to 2019
$2.5M
Receptors of RotavirusR56AI114831 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, XI · 2016 to 2016
$528k
Norovirus P Particle, A Multifunctional Platform For Vaccine DevelopmentR21AI092434 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI TAN, MING · 2011 to 2012
$421k
Norovirus Capsid: a Novel Drug TargetR21AI097936 · NIAID · UNIVERSITY OF CINCINNATI · PI MELLER, JAREK · 2013 to 2014
$392k
NCATS NIH HHS UL1 TR001425NIAID NIH HHS R01 AI089634NIAID NIH HHS R01 AI111095NIAID NIH HHS R01 AI123661NIAID NIH HHS R21 AI092434NIAID NIH HHS R21 AI097936NIAID NIH HHS R56 AI114831NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Homotypic interactions of viral capsid proteins are common, driving viral capsid self-formation. By taking advantage of such interactions of the norovirus shell (S) domain that naturally builds the interior shells of norovirus capsids, we have developed a technology to produce 60-valent, icosahedral S

Indexed as

BioengineeringAnimalsMiceMice, Inbred BALB CNanoparticlesRotavirusViral VaccinesViral Vaccinesdisulfide bondnorovirusnorovirus S particleprotein nanoparticlerotavirussubunit vaccinevaccine platform

Identifiers

PMID30234973
PMCPMC6261714
OpenAlexW2891976824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.