Evidence map›Paper›PMID 30234891›Full record

ArticleCardiology journal2020

Characteristics of circulating endothelial cells obtained from non-ST-segment elevation myocardial infarction patients with additional diastolic dysfunction of left ventricle observed in echocardiography.

Pawel Burchardt, Maura Farinacci, Magdalena Mayer, Klaus Luecke, Thomas Krahn, Jaroslaw Manczak, Marek Slomczynski, Jaroslaw Hiczkiewicz, Janusz Rzezniczak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Pawel BurchardtBiology of Lipid Disorders Department, Chair of Biology and Environmental Sciences, Poznan University of Medical Sciences, Poznan, Poland. pab2@tlen.pl.
Maura FarinacciInstitute for Medical Immunology, Berlin-Brandenburg Center für Regenerative Therapies, Core Unit Biomarker, Charité University Medicine, Berlin, Germany.
Magdalena MayerZablab sp. z o.o, Poznan, Poland.
Klaus LueckeHaimaChek Inc, Santa Monica, Santa Monica, CA,, United States.
Thomas KrahnBayer AG, Biomarker Research, Berlin, Germany.
Jaroslaw ManczakDepartment of Cardiology, J. Strus Hospital, Szwajcarska 3, 61-285 Poznan, Poland.
Marek SlomczynskiDepartment of Cardiology, J. Strus Hospital, Szwajcarska 3, 61-285 Poznan, Poland.
Jaroslaw HiczkiewiczDepartment of Cardiology, Hospital of Nowa Sol, Poland.
Janusz RzezniczakDepartment of Cardiology, J. Strus Hospital, Szwajcarska 3, 61-285 Poznan, Poland.
Bayer (Germany) · DECharité - Universitätsmedizin Berlin · DEPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating endothelial cells (CEC) may be used to find new strategies for the early di-agnosis of cardiovascular diseases. The major objective of the project is to broaden knowledge of CEC biology by determining their phenotypic characteristics. The additional aim is to clarify whether on the basis of these information it is possible to identify the origin of CEC release (from various cardiovascular compartments).

methodsCirculating endothelial cells were collected from arterial blood prior to angiography, as well as from arterial and venous blood obtained after angiography/coronary angioplasty, from 18 patients with non-ST-segment elevation myocardial infarction (NSTEMI). CECs were quantified by flow cytometry and defined as Syto16 (dye)+, CD45dim/neg, CD31+ and CD146+. The additional CD36+ was establish as a marker of endothelial cells released from small vessels of the microcirculation.

resultsThe total number of CECs increased significantly after the percutaneous transluminal coronary angioplasty (PTCA) in the arterial system. Number of CECs isolated at similar time points (after invasive procedure) did not differ significantly between arteries and veins, but the number of CD36+ CECs after coronary angioplasty was significantly higher in the venous system, than in the arterial system.

conclusionsThe number of CD36+ in artery samples obtained after coronary angioplasty (PTCA) had tendency to be decreased (in comparison to the sample obtained before angiography). It was major difference between those who had PTCA performed vs. those who had not.

Indexed as

EchocardiographyVentricular Function, LeftAgedBiomarkersCD146 AntigenCD36 AntigensCoronary AngiographyEndothelial CellsFemaleFlow CytometryHumansLeukocyte Common AntigensMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionBiomarkersCD146 AntigenCD36 AntigensCD36 protein, humanLeukocyte Common AntigensMCAM protein, humanPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1PTPRC protein, humancirculating endothelial cellsdiastolic dysfunctionNSTEMI

Identifiers

PMID30234891
PMCPMC8015987
OpenAlexW2891366938

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.