ArticleJournal of pediatric gastroenterology and nutrition2019
Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children.
Article in Journal of pediatric gastroenterology and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Etiology, case fatality, recurrence, and severity in pediatric acute pancreatitis: a meta-analysis of 48 studies.Pediatric research · 2022Pooled it
- Progression from acute to chronic pancreatitis in children: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2026Article
- Acute Pancreatitis in Children: It's Not Just a Simple Attack.Gastroenterology · 2025Review
- Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes.Journal of pediatric gastroenterology and nutrition · 2025Article
- Global, regional, and national burden of pancreatitis in children and adolescents.United European gastroenterology journal · 2025Article
- Patient and Family Input to Determine Experiences and Research Interests in Pediatric Pancreatitis: An INSPPIRE-2 Study.Pancreas · 2025Article
- Nutritional parameters following first episode of pediatric acute pancreatitis.Clinical nutrition ESPEN · 2024Observational
- The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Observational
- Acute pancreatitis is associated with gut dysbiosis in children.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2024Observational
- Pancreas volumes in pediatric patients following index acute pancreatitis and acute recurrent pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2024Article
- Review of acute pancreatitis in children in India.Journal of family medicine and primary care · 2024Review
- High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis.Pediatric diabetes · 2023Article
- Ultrasound findings of acute pancreatitis in children.Pediatric radiology · 2022Article
- Acute pancreatitis in children - morbidity and outcomes at 1 year.BMJ paediatrics open · 2022Article
- Acute Pancreatitis and Recurrent Acute Pancreatitis in Children: A 10-Year Retrospective Study.Gastroenterology research and practice · 2022Article
- Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis.PloS one · 2022Article
- Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China.BMC gastroenterology · 2021Article
- Risk factors of recurrent acute pancreatitis after conservative treatment in pediatric population: a single-center study.World journal of pediatric surgery · 2021Article
- Etiology of Acute Recurrent Pancreatitis in Vietnamese Children: an Initial Report.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- Drug induced pancreatitis is the leading known cause of first attack acute pancreatitis in children.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveResearch is lacking on the natural history of acute pancreatitis (AP) progression to acute recurrent pancreatitis (ARP). The aim of this project was to study the progression from AP to ARP among pediatric patients with pancreatitis to better understand the presentation and natural history of pancreatitis.
methodsPatients presenting with AP were included in a prospective database in Research Electronic Data Capture. We enrolled 115 patients with AP from March 2013 to November 2016. Physicians completed surveys regarding clinical data for patients with first attack of AP. Patients were followed prospectively, with data on progression entered when patients presented with ARP.
resultsThe most common etiologies for the first attack of AP were idiopathic (31%), toxic/drug-related (23%), and biliary/gallstone (18%). Twenty of the 115 patients (17%) developed ARP during the follow-up period. Seventy percent (14/20) of patients with ARP progressed from AP to ARP within 5 months from first diagnosis. A comparison of patients who rapidly progressed to ARP within 3 months (n = 12) to those followed for >3 months without progression in 3 months (n = 97) revealed associations with a higher weight percentile for age (P = 0.045), male sex (P = 0.03), and presence of pancreatic necrosis during first AP attack (P = 0.004). Progression to ARP significantly differed by etiology group with genetics having the highest risk for ARP progression over time and patients with gallstone/biliary, viral/systemic, and obstructive (nongallstone) having the lowest risk for ARP progression over time (P = 0.02).
conclusionsMost patients who progressed from AP to ARP progressed within 5 months. The presence of a higher weight percentile for age, male sex, and pancreatic necrosis during the first AP attack are associated with rapid progression to ARP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.