Evidence map›Paper›PMID 30234603›Full record

ArticleAIDS (London, England)2018

Probable antenatal depression at antiretroviral initiation and postpartum viral suppression and engagement in care.

Bryna J Harrington, Brian W Pence, Madalitso Maliwichi, Allan N Jumbe, Ntchindi A Gondwe, Shaphil D Wallie, Bradley N Gaynes, Joanna Maselko, William C Miller, Mina C Hosseinipour and 1 more

Abstract read
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bryna J HarringtonDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.
Brian W PenceDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.
Madalitso MaliwichiUNC Project Malawi, Lilongwe, Malawi.
Allan N JumbeUNC Project Malawi, Lilongwe, Malawi.
Ntchindi A GondweUNC Project Malawi, Lilongwe, Malawi.
Shaphil D WallieUNC Project Malawi, Lilongwe, Malawi.
Bradley N GaynesDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.
Joanna MaselkoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.
William C MillerCollege of Public Health, The Ohio State University, Columbus, Ohio, USA.
Mina C HosseinipourDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.
S4 Study team
University of North Carolina at Chapel Hill · USThe Ohio State University · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Option B+: ART Safety and Durability during First and Subsequent PregnanciesR01HD080485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HOSSEINIPOUR, MINA CHRISTINE · 2014 to 2019
$3.9M
Perinatal depression and key care outcomes in pregnant Malawian women with HIVF30MH111370 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRINGTON, BRYNA · 2016 to 2019
$130k
FIC NIH HHS R25 TW009340NIAID NIH HHS P30 AI050410NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD080485NIGMS NIH HHS T32 GM008719NIMH NIH HHS F30 MH111370
6 · The paper itself

Abstract

objectiveTo estimate the association of probable antenatal depression with postpartum HIV care engagement among pregnant women in Malawi.

designWe conducted a prospective cohort study of 299 women who were initiating antiretroviral therapy (ART) through Option B+ at a government antenatal clinic in Malawi.

methodsProbable antenatal depression was assessed on the day of ART initiation with the validated Chichewa version of the Edinburgh Postnatal Depression Scale (EPDS). We estimated crude and adjusted risk differences (RD, aRD) of visit attendance and prevalence differences (PD, aPD) of viral suppression through 12 months post-ART initiation comparing women with versus without probable antenatal depression.

resultsOne in 10 women had probable antenatal depression. Most women were engaged in care through 12 months post-ART initiation: 85% attended all scheduled ART visits, and 81% were in care and virally suppressed. Women with and without probable antenatal depression had a comparable probability of attending all scheduled visits (RD: -0.02; 95% CI -0.16 to 0.12; aRD: -0.04; 95% CI -0.18 to 0.10), and of viral suppression (PD: -0.02; 95% CI -0.17 to 0.13; aPD: -0.01; 95% CI -0.17 to 0.15) in crude and adjusted analyses.

conclusionProbable antenatal depression was not associated with engagement in HIV care through 12 months post-ART initiation. In a population with high HIV care engagement, antenatal depression may not impair HIV-related outcomes.

Indexed as

Sustained Virologic ResponseAdolescentAdultAnti-Retroviral AgentsDepressionFacilities and Services UtilizationFemaleHIV InfectionsHumansMalawiMedication AdherencePostpartum PeriodPregnancyPregnancy Complications, InfectiousPrevalenceProspective StudiesAnti-Retroviral Agents

Identifiers

PMID30234603
PMCPMC6528829
OpenAlexW2890435716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.