ArticleeLife2018
Persistent coding of outcome-predictive cue features in the rat nucleus accumbens.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.Science advances · 2025Article
- Nucleus Accumbens Shell Neurons Encode the Kinematics of Reward Approach Locomotion.Neuroscience · 2023Article
- Context coding in the mouse nucleus accumbens modulates motivationally relevant information.PLoS biology · 2022Article
- Silent Synapses in Cocaine-Associated Memory and Beyond.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico-basal ganglia systems.Hippocampus · 2020Review
- Learning of distant state predictions by the orbitofrontal cortex in humans.Nature communications · 2019Article
- Insensitivity of Place Cells to the Value of Spatial Goals in a Two-Choice Flexible Navigation Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Glutamate Afferents From the Medial Prefrontal Cortex Mediate Nucleus Accumbens Activation by Female Sexual Behavior.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus accumbens (NAc) is important for learning from feedback, and for biasing and invigorating behaviour in response to cues that predict motivationally relevant outcomes. NAc encodes outcome-related cue features such as the magnitude and identity of reward. However, little is known about how features of cues themselves are encoded. We designed a decision making task where rats learned multiple sets of outcome-predictive cues, and recorded single-unit activity in the NAc during performance. We found that coding of cue identity and location occurred alongside coding of expected outcome. Furthermore, this coding persisted both during a delay period, after the rat made a decision and was waiting for an outcome, and after the outcome was revealed. Encoding of cue features in the NAc may enable contextual modulation of on-going behaviour, and provide an eligibility trace of outcome-predictive stimuli for updating stimulus-outcome associations to inform future behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.