Evidence map›Paper›PMID 30234156›Full record

ArticleTransplantation direct2018

Autologous Mesenchymal Stromal Cells Prevent Transfusion-elicited Sensitization and Upregulate Transitional and Regulatory B Cells.

Zijian Zhang, Nancy A Wilson, Raghavan Chinnadurai, Sarah E Panzer, Robert R Redfield, Shannon R Reese, Jacques Galipeau, Arjang Djamali

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zijian ZhangDivision of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI.
Nancy A WilsonDivision of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI.
Raghavan ChinnaduraiDivision of Hematology-Oncology, Department of Medicine, University of Wisconsin, Madison, WI.
Sarah E PanzerDivision of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI.
Robert R RedfieldDivision of Transplant, Department of Surgery, University of Wisconsin, Madison, WI.
Shannon R ReeseDivision of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI.
Jacques GalipeauDivision of Hematology-Oncology, Department of Medicine, University of Wisconsin, Madison, WI.
Arjang DjamaliDivision of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI.
University of Wisconsin–Madison · US

Funding

Special BD LSR FortessaS10OD018202 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI PATANKAR, MANISH S · 2014 to 2014
$351k
NIH HHS S10 OD018202
6 · The paper itself

Abstract

backgroundWe hypothesized that immunomodulatory properties of mesenchymal stromal cells (MSC) may be considered for desensitization.

methodsAutologous or allogeneic bone marrow derived MSC were infused

resultsAt 4 weeks, pooled analyses demonstrated that autologous and allogeneic MSC were equally effective in reducing IgG1 and IgG2a de novo donor-specific antibody (dnDSA,

conclusionsOur findings indicate that autologous MSC prevent transfusion-elicited sensitization and upregulate transitional, and regulatory B cells. Additional studies are needed to determine the biological relevance of these changes after kidney transplantation.

Identifiers

PMID30234156
PMCPMC6133404
OpenAlexW2888990609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.