Evidence map›Paper›PMID 30234025›Full record

ArticleFrontiers in cellular and infection microbiology2018

Virtual Screening and Biomolecular Interactions of CviR-Based Quorum Sensing Inhibitors Against

Vinothkannan Ravichandran, Lin Zhong, Hailong Wang, Guangle Yu, Youming Zhang, Aiying Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Frontiers in microbiology · 2025
    Article
  5. Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
    Article
  6. Synthesis of the NovelACS omega · 2024
    Article
  7. Article
  8. Review
  9. Regulation of virulence inFrontiers in microbiology · 2024
    Review
  10. Inhibition of biofilm formation, quorum sensing and virulence factor production in Pseudomonas aeruginosa PAO1 by selected LasR inhibitors.International microbiology : the official journal of the Spanish Society for Microbiology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. The Derived Components ofMolecules (Basel, Switzerland) · 2022
    Article
  15. Article
  16. Veterinary world · 2022
    Article
  17. RepurposingAntibiotics (Basel, Switzerland) · 2022
    Article
  18. Computational and Biological Evaluation ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vinothkannan RavichandranState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Lin ZhongState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Hailong WangState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Guangle YuState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Youming ZhangState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Aiying LiState Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology (SHIB), School of Life Science, Shandong University, Qingdao, China.
Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of bacterial multi drug resistance becomes a global threat to the mankind. Therefore it is essential to find out alternate strategies to fight against these "super bugs." Quorum sensing (QS) is a cell-to-cell communication mechanism by which many bacteria regulate their biofilm and virulence factors expression to execute their pathogenesis. Hence, interfering the quorum sensing is an effective alternate strategy against various pathogens. In this study, we aimed to find out potential CviR-mediated quorum sensing inhibitors (QSIs) against

Indexed as

Drug Evaluation, PreclinicalAnti-Bacterial AgentsBiofilmsChromobacteriumGene Expression ProfilingIndolesMicroscopy, ConfocalPhytochemicalsQuorum SensingReal-Time Polymerase Chain ReactionAnti-Bacterial AgentsIndolesPhytochemicalsviolaceinbiofilm inhibition and microscale thermophoresisChromobacterium violaceumquorum sensingquorum sensing inhibitionvirtual screening

Identifiers

PMID30234025
PMCPMC6132053
OpenAlexW2891306787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.