ArticleEFORT open reviews2018
State-of-the-art diagnosis and surgical treatment of acute peri-prosthetic joint infection following primary total hip arthroplasty.
Article in EFORT open reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03714165 (Utility of Alpha Defensin and 16S rRNA Gene in Diagnosis of Prosthetic Joint Infection), which is not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utility of Alpha Defensin and 16S rRNA Gene in Diagnosis of Prosthetic Joint Infection
Who cites it
18 citing papers in PubMed.
- Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Management of Periprosthetic Joint Infections: A Multidisciplinary Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Prolonged wound drainage past two weeks is associated with increased treatment failure following prosthetic joint infection surgery of the hip.International orthopaedics · 2026Article
- Acute Prosthetic Joint Infection of Revision Total Hip Arthroplasty Managed with Debridement, Antibiotics, Implant Retention, and Flap Coverage: A Case Report.Journal of orthopaedic case reports · 2026Article
- The modified-KLICC score: a novel tool to predict outcomes following debridement, antibiotics, and implant retention after early acute periprosthetic hip infection.Bone & joint open · 2025Article
- Unconventional Therapies in Periprosthetic Joint Infections: Prevention and Treatment: A Narrative Review.Journal of clinical medicine · 2025Review
- Periprosthetic Joint Infection (PJI).The archives of bone and joint surgery · 2025Review
- Diagnostic accuracy of alpha-defensin ELISA and lateral flow assays for periprosthetic joint infection: a systematic review and meta-analysis.Journal of bone and joint infection · 2025Review
- Higher Onset of Periprosthetic Joint Infections in Patients With Teeth Compared to Those Without Teeth.Cureus · 2024Article
- Current updates in MSK infection imaging: A narrative review.Journal of clinical orthopaedics and trauma · 2024Article
- Articulating Hip Spacers with a Constrained Acetabular Liner: Effect of Acetabular Bone Loss and Cementation Quality.Antibiotics (Basel, Switzerland) · 2023Article
- Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings.Materials (Basel, Switzerland) · 2022Article
- Dair approach in 7 infected total hip arthroplasties: our experience and current concepts of the literature.Acta bio-medica : Atenei Parmensis · 2022Review
- [Experimental study of silkworm larvae plasma colorimetry based on immune cascade reaction in accurate diagnosis of periprosthetic joint infection].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Article
- Management strategies for prosthetic joint infection: long-term infection control rates, overall survival rates, functional and quality of life outcomes.EFORT open reviews · 2021Review
- Time-dependent efficacy of combination of silver-containing hydroxyapatite coating and vancomycin on methicillin-resistant Staphylococcus aureus biofilm formation in vitro.BMC research notes · 2021Article
- Loosening of total knee arthroplasty - always aseptic?Journal of clinical orthopaedics and trauma · 2020Article
- Debridement, Antibiotics, and Implant Retention with the Direct Anterior Approach for Acute Periprosthetic Joint Infection Following Primary THA.JB & JS open accessArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute peri-prosthetic joint infection (PJI) following total hip arthroplasty (THA) is a potentially devastating and undesired complication, with a prevalence of 0.3% to 2.9%. Its suspicion begins with a meticulous physical examination and anamnesis. Diagnosis should be made on the basis of the Musculoskeletal Infection Society criteria. Serum and synovial biomarkers are very useful tools when major criteria are absent.Although sometimes not possible due to medical conditions, surgery is usually the first line of treatment. Although its outcome is highly correlated with the isolated microorganism, irrigation and debridement with implant retention (DAIR) is the gold standard for treatment. Ideally, the prior approach should be proximally and distally extended to augment the field of view and remove all of the prosthetic modular components, that is, femoral head and acetabular insert.Given DAIR's unclear control of infection, with successful outcomes in the range of 30% to 95%, one- or two-stage revision protocols may play a role in certain cases of acute infections; nonetheless, further prospective, randomized studies are necessary to compare long-term outcomes between DAIR and revision surgeries.Following surgical treatment, length of antibiotherapy is in the range of six weeks to six months, without any difference in outcomes between short and long protocols. Treatment should be adjusted to the isolated bacteria and controlled further with post-operative serum biomarker levels. Cite this article:
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