ArticleExperimental and therapeutic medicine2018
Evaluation of the potential of chicoric acid as a natural food antioxidant.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- Pharmacokinetics and antioxidant activity of dihydrocaffeic acid grafted chitosan nanomicelles loaded with chicoric acid in broilers.Poultry science · 2024Article
- Extraction Optimization, Antioxidant, Cosmeceutical and Wound Healing Potential ofMolecules (Basel, Switzerland) · 2023Article
- The intestinal absorption mechanism of chicoric acid and its bioavailability improvement with chitosan.Heliyon · 2022Article
- Antiradical properties of curcumin, caffeic acid phenethyl ester, and chicoric acid: a DFT study.Journal of molecular modeling · 2022Article
- First Insight into Nutraceutical Properties of Local SalentoInternational journal of environmental research and public health · 2021Article
- Article
- The Protective Effect ofNutrients · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary fat is important for human health, while its excessive consumption or the oxidation of lipids may cause various diseases. In the present study, the potential of chicoric acid (CA) as a natural food antioxidant was evaluated. To evaluate this, spectrophotometry analysis measured CA antioxidant activity, the analytical method of the sanitary standard of edible lard and rapeseed oil measured CA anti-oil oxidation, the Oxford cup method measured CA anti-microbial activity, Oil red O staining assessed intracellular triglycerides following CA administration, and RT-qPCR analysis and ELISA assessed CA anti-inflammatory activity. The results indicated that CA had a marked scavenging capacity for the 2,2-diphenyl-1-picrylhydrazyl radical, as well as a reductive action, and after incubation for 5 days, 0.05% CA achieved a significantly higher peroxide value than 0.02% tert-butylhydroquinone used as a reference (P<0.05). In addition, 160 nM CA inhibited the growth of a variety of common pathogenic microbes in humans, significantly inhibited fat droplet formation (P<0.05) and reduced the production of interleukin-1β and tumor necrosis factor-α in a dose-dependent manner (P<0.05). Therefore, functional foods containing CA may be used as natural antioxidant supplements to prevent the oxidation of oil and protect human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.