Evidence map›Paper›PMID 30233592›Full record

ArticleFrontiers in immunology2018

Hematopoietic Stem/Progenitor Cell Dependent Participation of Innate Lymphoid Cells in Low-Intensity Sterile Inflammation.

Sarantis Korniotis, Thomas B Thornley, Periklis Kyriazis, Evangelos Theodorou, Lingzhi Ma, Lisa S Li, Efi Kokkotou, Terry B Strom, Maria Koulmanda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Interaction between Joint Inflammation and Cartilage Repair.Tissue engineering and regenerative medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sarantis KorniotisDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Thomas B ThornleyDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Periklis KyriazisDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Evangelos TheodorouDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Lingzhi MaDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Lisa S LiDepartment of Surgery, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Efi KokkotouDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Terry B StromDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Maria KoulmandaDepartment of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, MA, United States.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

Taming inflammation to create transplant toleranceU01AI102427 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOULMANDA, MARIA, STROM, TERRY B. · 2012 to 2016
$4.0M
Pre-clinical evaluation of a neutrophil elastase inhibitor for the treatment of inflammatory bowel diseaseR21TR001753 · NCATS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOKKOTOU, EFI G. · 2016 to 2017
$692k
NCATS NIH HHS R21 TR001753NIAID NIH HHS U01 AI102427
6 · The paper itself

Abstract

Hematopoietic stem/progenitor cells (HSPC) are characterized by their unique capacities of self-renewal and multi-differentiation potential. This second property makes them able to adapt their differentiation profile depending on the local environment they reach. Taking advantage of an animal model of peritonitis, induced by injection of the TLR-2 ligand, zymosan, we sought to study the relationship between bone marrow-derived hematopoietic stem/progenitor cells (BM-HSPCs) and innate lymphoid cells (ILCs) regarding their emergence and differentiation at the site of inflammation. Our results demonstrate that the strength of the inflammatory signals affects the capacity of BM-derived HSPCs to migrate and give rise

Indexed as

AnimalsBone Marrow CellsCell DifferentiationCell MovementCells, CulturedCell Self RenewalDisease Models, AnimalFemaleHematopoietic Stem CellsHumansImmunity, InnateLymphocytesMiceMice, Inbred C57BLPeritonitisSignal TransductionZymosanCCR2hematopoietic stem cellsinnate lymphoid cells (ILC)sterile inflammationzymosan

Identifiers

PMID30233592
PMCPMC6134892
OpenAlexW2891658737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.